• Publications
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Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.
Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a majorExpand
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Dosage sensitivity and the evolution of gene families in yeast
According to what we term the balance hypothesis, an imbalance in the concentration of the subcomponents of a protein–protein complex can be deleterious. If so, there are two consequences: first,Expand
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The incidences and evolution of cytoplasmic male killers
  • L. Hurst
  • Biology
  • Proceedings of the Royal Society of London…
  • 22 May 1991
Two types of male-killing cytoplasmic gene are distinguished by their time of action. Early male killers strike embryos, whereas late killers, so far only observed in mosquitoes, kill fourth instarExpand
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Highly expressed genes in yeast evolve slowly.
THE rate of protein evolution shows considerable variation among genes. This variation is thought to reflect differences in the proportion of the sequence that is critical to fulfill given functionsExpand
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The Ka/Ks ratio: diagnosing the form of sequence evolution.
  • L. Hurst
  • Medicine, Biology
  • Trends in genetics : TIG
  • 1 September 2002
  • 579
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The signature of selection mediated by expression on human genes.
As the efficacy of natural selection is expected to be a function of population size, in humans it is usually presumed that selection is a weak force and hence that gene characteristics are mostlyExpand
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The evolutionary dynamics of eukaryotic gene order
In eukaryotes, unlike in bacteria, gene order has typically been assumed to be random. However, the first statistically rigorous analyses of complete genomes, together with the availability ofExpand
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Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes.
In many eukaryotic species, gene order is not random. In humans, flies, and yeast, there is clustering of coexpressed genes that cannot be explained as a trivial consequence of tandem duplication. InExpand
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Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells
Naive embryonic stem cells hold great promise for research and therapeutics as they have broad and robust developmental potential. While such cells are readily derived from mouse blastocysts it hasExpand
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The evolution of isochores
One of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of theExpand
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