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Determination of endogenous formaldehyde in plants (fruits) bound to L-arginine and its relation to the folate cycle, photosynthesis and apoptosis.
A very powerful nucleophilic reagent, hydralazine(1-hydrazino-phtalazine) proved to be suitable for determination of the endogenous formaldehyde level in biological samples. It was found that in… Expand
Prognostic Significance of the Thymidylate Biosynthetic Enzymes in Human Colorectal Tumors
The aim of the present study was to determine the relative intratumoral activity of two pyrimidine biosynthetic enzymes, i.e. thymidylate synthase (TS) and thymidine kinase (TK), in human colorectal… Expand
FORMATION OF BURST CHEMILUMINESCENCE, EXCITED ALDEHYDES, AND SINGLET OXYGEN IN MODEL REACTIONS AND FROM CARCINOGENIC COMPOUNDS IN RAT LIVER S9 FRACTIONS
It is shown that in physiological circumstances (T=298 K, pH=7.4) various aldehydes (formaldehyde, acetaldehyde, glyoxal, methyl-glyoxal, etc.) can be activated by hydrogen peroxide (H202) in the… Expand
A comparison of the tumor growth inhibitory effect of intermittent and continuous administration of the somatostatin structural derivative TT-232 in various human tumor models.
The tumor growth inhibitory efficacy of the somatostatin structural derivative TT-232 was studied using different routes of administration and treatment schedules in various human tumor models.… Expand
Activation of Deoxycytidine Kinase by Various Nucleoside Analogues
The effect of different nucleoside analogues on deoxycytidine kinase (dCK) and thymidine kinase (TK) was compared in normal human lymphocytes and various leukemic cell lines. G-phase enriched… Expand
Antagonistic reactions of arginine and lysine against formaldehyde and their relation to cell proliferation, apoptosis, folate cycle and photosynthesis
- L. Trézl, L. Hullán, +7 authors L. Toeke
- Medicine, Chemistry
- Molecular and Cellular Biochemistry
- 1 February 2003
Abstract1H, 13C NMR, ESMS and MS/MS investigations proved that there is an antagonism in the spontaneous reaction of formaldehyde with L-lysine and L-arginine. L-Arginine can only be… Expand
Endogenous formaldehyde level of foods and its biological significance
Abstract Formaldehyde was measured in different food samples based on its reaction with hydralazine to form s-triazolo-(3,4-α)-phthalazine(Tri-P). Formaldehyde reacts with hydralazine under mild… Expand
Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models.
- M. Tejeda, D. Gaál, L. Hullán, B. Hegymegi-Barakonyi, G. Kéri
- Medicine, Biology
- Anticancer research
- 1 September 2006
The antitumor effects of the somatostatin structural derivative TT-232 in different rodent and xenograft tumor models are summarized in this report. TT-232 had previously been shown to inhibit the… Expand
Novel advances in the regulation of signal transduction activity.
Continuous administration of the somatostatin structural derivative /TT-232/ by subcutaneously implanted osmotic pump improves the efficacy and potency of antitumor therapy in different mouse and…
BACKGROUND The somatostatin structural derivative, TT-232, has a special 5-residue ring structure (D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2) and very different characteristics from the known growth… Expand