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Identification of influenza A nucleoprotein as an antiviral target
Influenza A remains a significant public health challenge because of the emergence of antigenically shifted or highly virulent strains. Antiviral resistance to available drugs such as adamantanes or… Expand
Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both β-Amyloid Production and Clearance
Alzheimer's disease (AD) chiefly characterizes a progressively neurodegenerative disorder of the brain, and eventually leads to irreversible loss of intellectual abilities. The β-amyloid (Aβ)-induced… Expand
D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin.
- Dalei Wu, Yunhua Kong, +4 authors Xu Shen
- Chemistry, Medicine
- International journal of antimicrobial agents
- 1 November 2008
Flavonoids are polyphenolic compounds that are ubiquitous in nature. They possess varied promising properties for medical use. Quercetin (3,3',4',5,7-pentahydroxyflavone) and apigenin… Expand
Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori
Shikimate dehydrogenase (SDH) is the fourth enzyme involved in the shikimate pathway. It catalyzes the NADPH‐dependent reduction of 3‐dehydroshikimate to shikimate, and has been developed as a… Expand
Study of the mechanical, thermal properties and flame retardancy of rigid polyurethane foams prepared from modified castor-oil-based polyols
Po1lyurethane foams (PUFs) were prepared using modified castor-oil-based polyols (MCOs). In the first stage, castor oil (CO) was converted into monoglycerides and diglycerides by alcoholysis with… Expand
Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers.
- J. Li, A. L. Risinger, J. Peng, Z. Chen, L. Hu, S. Mooberry
- Chemistry, Medicine
- Journal of the American Chemical Society
- 30 November 2011
The taccalonolides are a class of microtubule stabilizing agents isolated from plants of the genus Tacca. In efforts to define their structure-activity relationships, we isolated five new… Expand
METHODS TO IMPROVE LIGNIN’S REACTIVITY AS A PHENOL SUBSTITUTE AND AS REPLACEMENT FOR OTHER PHENOLIC COMPOUNDS: A BRIEF REVIEW
Lignin is readily available as a by-product from the pulp and paper industry. It is considered to be a promising substitute for phenol in phenol-formaldehyde (PF) resin synthesis, given the… Expand
Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism.
Selectively eradicating cancer cells with minimum adverse effects on normal cells is a major challenge in the development of anticancer therapy. We hypothesize that nutrient-limiting conditions… Expand
Small molecules from natural sources, targeting signaling pathways in diabetes.
- Qiong Liu, Li-li Chen, L. Hu, Yue-Wei Guo, Xu Shen
- Biology, Medicine
- Biochimica et biophysica acta
- 1 October 2010
Diabetes mellitus (DM) is a metabolic disease caused by genetic or environmental factors. It has rendered a severe menace to the middle-aged and elderly, while there is still lack of efficient drugs… Expand
Activation of Protein Serine/Threonine Phosphatase PP2Cα Efficiently Prevents Liver Fibrosis
Background Over-activation of TGFβ signaling pathway and uncontrolled cell proliferation of hepatic stellate cells (HSCs) play pivotal roles in liver fibrogenesis, while the protein serine/threonine… Expand