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Initial sequencing and analysis of the human genome.

• Eric S. Lander, Linda Linton, +251 authors Y. J. Chen
• Nature
• 2001

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and… (More)

Integrated genomic and proteomic analyses of a systematically perturbed metabolic network.

• Trey Ideker, Vesteinn Thorsson, +7 authors L. Hood
• Science
• 2001

We demonstrate an integrated approach to build, test, and refine a model of a cellular pathway, in which perturbations to critical pathway components are analyzed using DNA microarrays, quantitative… (More)

A new approach to decoding life: systems biology.

• Trey Ideker, Timothy Galitski, L. Hood
• Annual review of genomics and human genetics
• 2001

Systems biology studies biological systems by systematically perturbing them (biologically, genetically, or chemically); monitoring the gene, protein, and informational pathway responses; integrating… (More)

Genome sequence of Halobacterium species NRC-1.

• Wilfred Ng, Scott P Kennedy, +40 authors S Dassarma
• Proceedings of the National Academy of Sciences…
• 2000

We report the complete sequence of an extreme halophile, Halobacterium sp. NRC-1, harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 families and organized into… (More)

Auditory neuropathy.

• Albert Starr, T. W. Picton, Yvonne S. Sininger, L. Hood, Conny Berlin
• Brain : a journal of neurology
• 1996

Ten patients presented as children or young adults with hearing impairments that, by behavioural and physiological testing, were compatible with a disorder of the auditory portion of the VIII cranial… (More)

The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.

• Lee Rowen, B. F. Koop, L. Hood
• Science
• 1996

The human beta T cell receptor (TCR) locus, comprising a complex family of genes, has been sequenced. The locus contains two types of coding elements--TCR elements (65 variable gene segments and two… (More)

Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence.

• Scott P Kennedy, Wilfred Ng, Steven L Salzberg, L. Hood, S Dassarma
• Genome research
• 2001

The genome of the halophilic archaeon Halobacterium sp. NRC-1 and predicted proteome have been analyzed by computational methods and reveal characteristics relevant to life in an extreme environment… (More)

Pulsed field gel electrophoresis.

• E. Lai, Bruce W. Birren, S. M. Clark, M. I. Simon, L. Hood
• BioTechniques
• 1989

Mutations in the connexin 26 gene (GJB2) among Ashkenazi Jews with nonsyndromic recessive deafness.

• Randy Morell, H. J. Kim, +9 authors Thomas B Friedman
• The New England journal of medicine
• 1998

BACKGROUND Mutations in the GJB2 gene cause one form of nonsyndromic recessive deafness. Among Mediterranean Europeans, more than 80 percent of cases of nonsyndromic recessive deafness result from… (More)

A common language for physical mapping of the human genome.

• Maynard V. Olson, L. Hood, Charles R. Cantor, David Botstein
• Science
• 1989

I N A REPORT ISSUED IN JANUARY 1988, THE NATIONAL Research Council (NRC) Committee on the Mapping and Sequencing of the Human Genome, on which the present authors served, recommended a staged mapping… (More)

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