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Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Neuromotor prostheses (NMPs) aim to replace or restore lost motor functions in paralysed humans by routeing movement-related signals from the brain, around damaged parts of the nervous system, toExpand
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Reach and grasp by people with tetraplegia using a neurally controlled robotic arm
Paralysis following spinal cord injury, brainstem stroke, amyotrophic lateral sclerosis and other disorders can disconnect the brain from the body, eliminating the ability to perform volitionalExpand
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Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia.
Computer-mediated connections between human motor cortical neurons and assistive devices promise to improve or restore lost function in people with paralysis. Recently, a pilot clinical study of anExpand
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Single-neuron dynamics in human focal epilepsy
Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we report the firstExpand
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Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness
The neurophysiological mechanisms by which anesthetic drugs cause loss of consciousness are poorly understood. Anesthetic actions at the molecular, cellular, and systems levels have been studied inExpand
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Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array.
The ongoing pilot clinical trial of the BrainGate neural interface system aims in part to assess the feasibility of using neural activity obtained from a small-scale, chronically implanted,Expand
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Collective dynamics in human and monkey sensorimotor cortex: predicting single neuron spikes
Coordinated spiking activity in neuronal ensembles, in local networks and across multiple cortical areas, is thought to provide the neural basis for cognition and adaptive behavior. Examining suchExpand
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Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex.
Epileptic cortex is characterized by paroxysmal electrical discharges. Analysis of these interictal discharges typically manifests as spike-wave complexes on electroencephalography, and plays aExpand
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Primary Motor Cortex Tuning to Intended Movement Kinematics in Humans with Tetraplegia
The relationship between spiking activities in motor cortex and movement kinematics has been well studied in neurologically intact nonhuman primates. We examined the relationship between spikingExpand
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Early detection of consciousness in patients with acute severe traumatic brain injury
&NA; See Schiff (doi:10.1093/awx209) for a scientific commentary on this article. Patients with acute severe traumatic brain injury may recover consciousness before self‐expression. WithoutExpand
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