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Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
TLDR
The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.
Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals
TLDR
It is reported that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection, and its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied.
MAIT cells are activated during human viral infections
TLDR
It is demonstrated that MAIT cells are activated following viral infections, and a potential role in both host defence and immunopathology is suggested.
Longitudinal COVID-19 profiling associates IL-1Ra and IL-10 with disease severity and RANTES with mild disease.
TLDR
The chemokine RANTES(CCL5) was significantly elevated, from an early stage of the infection, in patients with mild but not severe disease, and early production of inhibitory mediators including IL-10 and IL-1RA were significantly associated with disease severity, suggesting early intervention to increase expression of CCL5 may prevent patients from developing severe illness.
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.
TLDR
This work analyzes and compares the transcriptome and proteome of human and murine macrophages under resting conditions (M0) and after IL-4 activation (M2) and provides a resource for tools enabling macrophage detection in human tissues by identifying a set of 87 Macrophage-related genes.
Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers
TLDR
Tuberculosis and sarcoidosis revealed similar blood transcriptional profiles, dominated by interferon-inducible transcripts, while pneumonia and lung cancer showed distinct signatures,dominated by inflammatory genes.
Hepcidin regulation by innate immune and infectious stimuli.
TLDR
Results indicate that hepcidin induction represents a component of the innate immune response to acute infection, with the potential to affect disease pathogenesis.
Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
TLDR
The level of gene transfer and functional correction were comparable to those reported previously using adenoviral vectors or another DNA–liposome complex, but here were sustained and uncompromised by false positives.
Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide
TLDR
Nitrite levels in breath condensate were raised in stable patients with cystic fibrosis in contrast to exhaled NO, suggesting that nitrite levels may be a more useful measure of NO production and possibly airways inflammation in suppurative airways and that exhaled No may not reflect total NO production.
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