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Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system
Studies have focused on the events that influence the development of interleukin 17 (IL-17)–producing T helper cells (TH-17 cells) associated with autoimmunity, such as experimental autoimmuneExpand
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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the pathophysiology of inflammatory diseases andExpand
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Cre-mediated gene deletion in the mammary gland.
To delete genes specifically from mammary tissue using the Cre-lox system, we have established transgenic mice expressing Cre recombinase under control of the WAP gene promoter and the MMTV LTR. CreExpand
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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
Cre-mediated excision of exon 11 of the breast-tumour suppressor gene Brca1 in mouse mammary epithelial cells causes increased apoptosis and abnormal ductal development. Mammary tumour formationExpand
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Stat5a is mandatory for adult mammary gland development and lactogenesis.
Prolactin (PRL) induces mammary gland development (defined as mammopoiesis) and lactogenesis. Binding of PRL to its receptor leads to the phosphorylation and activation of STAT (signal transducersExpand
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Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
Suppressor of cytokine signaling (Socs) 3 is a cytokine-inducible inhibitor with critical but selective cell-specific effects. We show that deficiency of Socs3 in T cells had minimal effects onExpand
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Information networks in the mammary gland
Unique developmental features during puberty, pregnancy, lactation and post-lactation make the mammary gland a prime object to explore genetic circuits that control the specification, proliferation,Expand
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Nonredundant roles for Stat5a/b in directly regulating Foxp3.
Stats (signal transducers and activators of transcription) regulate multiple aspects of T-cell fate. T regulatory (Treg) cells are a critical subset that limits immune responses, but the relativeExpand
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Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution.
  • M. Li, X. Liu, +5 authors P. Furth
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 April 1997
Programmed cell death (PCD) of mammary alveolar cells during involution commences within hours of the end of suckling. Locally, milk accumulates within alveolar lumens; systemically, levels ofExpand
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Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation
ABSTRACT This study explored the functions of the signal transducers and activators of transcription 5a and 5b (referred to as Stat5 here) during different stages of mouse mammary gland developmentExpand
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