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Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system
It is shown that IL-27 receptor–deficient mice chronically infected with Toxoplasma gondii developed severe neuroinflammation that was CD4+ T cell dependent and was associated with a prominent IL-17 response.
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
It is demonstrated that disruption of Brca1 causes genetic instability and triggers further alterations, including the inactivation of p53, that lead to tumour formation.
Cre-mediated gene deletion in the mammary gland.
The results show that transgenic mice with WAP-Cre but not MMTV-Cre can be used as a powerful tool to study gene function in development and tumorigenesis in the mammary gland.
Stat5a is mandatory for adult mammary gland development and lactogenesis.
- X. Liu, G. Robinson, K. Wagner, L. Garrett, A. Wynshaw-Boris, L. Hennighausen
- BiologyGenes & development
- 15 January 1997
It is document that Stat5a is the principal and an obligate mediator of mammopoietic and lactogenic signaling.
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
It is concluded that Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of Th17 differentiation.
Information networks in the mammary gland
Unique developmental features during puberty, pregnancy, lactation and post-lactation make the mammary gland a prime object to explore genetic circuits that control the specification, proliferation,…
Nonredundant roles for Stat5a/b in directly regulating Foxp3.
It is concluded that Stat5a/b have an essential, nonredundant role in regulating Treg cells, and that Stat3 and Stat5 a/b appear to have opposing roles in the regulation of Foxp3.
Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution.
- M. Li, X. Liu, P. Furth
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 April 1997
It is demonstrated that genetic events that occur during the first reversible stage of mammary gland involution are controlled by local factors and mammary-derived death signals are dominant over protective effects related to systemic hormone stimulation.
Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice
The results show that MMTV-mediated Cre-activation is restricted to specific cell types of various secretory tissues and the hematopoietic system, and the timing of Cre expression varies between tissues and cell types, suggesting a strong influence of steroid hormones on the transcriptional activation of theMMTV-LTR.