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Bioceramics: From Concept to Clinic
Ceramics used for the repair and reconstruction of diseased or damaged parts of the musculo-skeletal system, termed bioceramics, may be bioinert (alumina, zirconia), resorbable (tricalciumExpand
The story of Bioglass®
  • L. Hench
  • Materials Science, Medicine
  • Journal of materials science. Materials in…
  • 22 November 2006
TLDR
The 40 year history of the development of bioactive glasses is reviewed, with emphasis on the first composition, 45S5 Bioglass®, that has been in clinical use since 1985, and the steps of discovery, characterization, in vivo and in vitro evaluation, clinical studies and product development are summarized along with the technology transfer processes. Expand
Bonding mechanisms at the interface of ceramic prosthetic materials
The development of a bone-bonding calcia-phosposilicate glass-ceramic is discussed. A theoretical model to explain the interfacial bonding is based upon in-vitro studies of glass-ceramic solubilityExpand
Third-Generation Biomedical Materials
TLDR
The next generation of biomaterials is combining these two properties, with the aim of developing materials that, once implanted, will help the body heal itself. Expand
An Introduction to Bioceramics
Alumina and zirconia, S. Hulbert bioactive glasses - materials science, L. Hench and O. Andersson bioactive glasses-materails science, L. Hench and O. Anderson applications, J. Wilson and R.P.Expand
The Sol-Gel Process
An investigation of bioactive glass powders by sol-gel processing.
  • R. Li, A. Clark, L. Hench
  • Materials Science, Medicine
  • Journal of applied biomaterials : an official…
  • 1 December 1991
TLDR
The results indicate that it is possible to significantly expand the bioactive composition range through microstructural control made possible by sol-gel processing techniques. Expand
Effect of crystallization on apatite-layer formation of bioactive glass 45S5.
TLDR
F Fourier-transform infrared (FTIR) spectroscopy was used to determine the rate of hydroxycarbonate apatite (HCA) formation that occurs on bioactive glass and glass-ceramic implants when exposed to simulated body fluid (SBF) solutions. Expand
Spectroscopic study of human lung epithelial cells (A549) in culture: living cells versus dead cells.
TLDR
The capability of Raman spectroscopy for use as a noninvasive method to distinguish cells at different stages of the cell cycle and living cells from dead cells is shown. Expand
Biomaterials: a forecast for the future.
  • L. Hench
  • Engineering, Medicine
  • Biomaterials
  • 1 August 1998
TLDR
It is proposed that biomaterials research needs to focus on regeneration of tissues instead of replacement, and hierarchical bioactive scaffolds to engineer in vitro living cellular constructs for transplantation, or use resorbable bioactive particulates or porous networks to activate the mechanisms of tissue regeneration. Expand
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