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The swi4+ gene of Schizosaccharomyces pombe encodes a homologue of mismatch repair enzymes.
TLDR
The swi4+ gene of Schizosaccharomyces pombe is involved in termination of copy-synthesis during mating-type switching and shows homology to Duc-1 (human), Rep-3 (mouse), HexA (Streptococcus pneumoniae) and MutS (Salmonella typhimurium).
The switching gene swi6 affects recombination and gene expression in the mating-type region of Schizosaccharomyces pombe
TLDR
Besides reducing MT switching, the swi6 mutation leads to deletions in the MT region caused by intrachromosomal cross-overs between two paired cassettes, which may have an influence on the general chromatin structure in theMT region.
Molecular characterization of h− mutants of Schizosaccharomyces pombe
TLDR
Southern analyses of 23 “class II” mutants made of mat2:2 mutants of Schizosaccharomyces pombe found some distinct differences as to the intensity of the bands in the blots; the class Ilb mutants have strong bands characteristic of lethal deletions (h−L) and mat1:10 plasmids.
Construction of an h+Sstrain of Schizosaccharomyces pombe
  • L. Heim
  • Biology
    Current Genetics
  • 2004
TLDR
An h+ strain was obtained which neither mutates to h- nor to h90, and southern blotting showed that it possesses the same mating-type (MT) configuration as h-S except that P information resides in both cassettes.
A mutated swi4 gene causes duplications in the mating-type region of Schizosaccharomyces pombe
SummaryEfficient mating-type (MT) switching in homothallic strains of Schizosaccharomyces pombe is significantly reduced if they have a mutation in any of the eleven known swi genes. The swi4
Construction of an h+S strain of Schizosaccharomyces pombe.
  • L. Heim
  • Medicine
    Current genetics
  • 1990
By spontaneous in vivo integration of a mat2:1 degrees plasmid, containing a Plus (P) cassette, into an h-L MT region of Schizosaccharomyces pombe an h+ strain was obtained which neither mutates to
Rescue of lethal mutations in the mating-type region of Schizosaccharomyces pombe by an extrachromosomal element
TLDR
In tetrads of h+L/h-S strains the authors found some viable h-S spores yielding colonies with a weak iodine reaction and the L region of the plasmid can compensate the chromosomal h-L deletion.