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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
It is found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes, and the role of insulin/IGF signaling in regulating animal aging is evolutionarily conserved. Expand
The Physiology of Life History Trade-Offs in Animals
A review of life historyTrade-offs discusses conceptual issues associated with physiological aspects of trade-offs, and it describes recent advances on this topic. Expand
Factors affecting the distribution of cytoplasmic incompatibility in Drosophila simulans.
Fitness comparisons of infected and uninfected stocks, including both larval and adult fitness components, indicate that fecundity may be the component most affected, and a theoretical analysis provides some insight into the population biology of the infection. Expand
Extensive Sex-Specific Nonadditivity of Gene Expression in Drosophila melanogaster
Comparison of adults of two isogenic lines and their reciprocal F1 hybrids revealed 5820 genes as significantly different between at least two of the four genotypes in either males or females or across both sexes, suggesting that heterosis for expression is rare. Expand
The cost of reproduction: the devil in the details.
Recent studies in five areas examining the proximate mechanisms underlying the cost of reproduction provide new information about mechanisms that comprise 'the cost', but also hint at an underlying evolutionarily conserved causal mechanism. Expand
Variation in sperm displacement and its association with accessory gland protein loci in Drosophila melanogaster.
A screen for variation in sperm displacement among 152 lines of Drosophilia melanogaster that were made homozygous for second and/or third chromosomes recovered from natural populations found no correlation between the able to displace resident sperm and the ability to resist being displaced by subsequent sperm. Expand
Desiccation and starvation resistance in Drosophila: patterns of variation at the species, population and intrapopulation levels
Drosophila studies have investigated variation in desiccation and starvation resistance, providing an opportunity to test for consistent patterns of direct and correlated responses across studies and across the species and population levels. Expand
Endocrinology: The Developing Synthesis between Endocrinology and Evolutionary Genetics
Concentrations of circulating hormones and the activities of titer regulators are focused on, and variation in brain neurohormones, bone-regulating hormones, and hormone receptor gene sequences that underlie ecologically important genetic polymorphisms are identified. Expand
Stress resistance and longevity in selected lines of Drosophila melanogaster☆
Five independent populations (lines) of Drosophila melanogaster were selected for female starvation resistance. Females and males from the selected lines were relatively starvation resistant whenExpand
Increased transsulfuration mediates longevity and dietary restriction in Drosophila
Drosophila cystathionine β-synthase (dCBS), which catalyzes the rate-determining step in the TSP, is a positive regulator of lifespan in DrosophILA and that the pathway is required for the effects of diet restriction on animal physiology and lifespan is shown. Expand