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Platelet-active drugs: the relationships among dose, effectiveness, and side effects.
Abbreviations: ACE trial 5 Acetylsalicylic Acid and Carotid Endarterectomy; CAPRIE study 5 Clopidogrel vs Aspirin in Patients at Risk of Ischemic Events; CI 5 confidence interval; COX 5 cyclooxygenase; DVT 5 deep venous thrombosis; EPISTENT trial 5 Evaluation of Platelet IIb/IIIa Inhibitors for Stenting.
A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro.
- R. Ross, J. Glomset, B. Kariya, L. Harker
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 April 1974
Much of the growth-promoting activity of dialyzed serum is directly or indirectly derived from platelets, which has important implications for the response of arteries to localized injury and provides a key to further understanding of the role of factors derived from blood serum in promoting cell proliferation in vitro.
Neutrophil kinetics in man.
- J. T. Dancey, K. Deubelbeiss, L. Harker, C. Finch
- Medicine, BiologyJournal of Clinical Investigation
- 1 September 1976
Neutrophil maturational categories, defined by morphologic criteria, were supported by autoradiographs of marrow flashed-labeled with 3H-thymidine and diisopropylfluorophosphate-32P and correlated well with the calculation of marrow neutrophil production.
Thrombogenesis in sickle cell disease.
- A. Tomer, L. Harker, S. Kasey, J. Eckman
- Medicine, BiologyThe Journal of laboratory and clinical medicine
- 1 June 2001
Asymptomatic subjects with SCD exhibit ongoing platelet activation, thrombin generation, and fibrinolysis that increases during episodes of pain, thereby implicating thrombogenic activity in the development of SCD pain episodes.
Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release.
It is concluded that cardiopulmonary bypass patients demonstrate abnormal clinical bleeding when there is a persistence of platelet dysfunction manifested as a bleeding time of greater than 20 mm after protamine administration and such bleeding patients with a prolonged bleeding time should receive platelet transfusions.
Bleeding complications associated with cardiopulmonary bypass.
The protease inhibitor aprotinin is particularly promising in the reduction of bleeding associated with CPB when given prophylactically and may provide new insights into the mechanism of CPB-induced platelet dysfunction.
Exaggerated platelet reactivity in major depression.
Depressed patients exhibit enhanced baseline platelet activation and responsiveness in comparison with normal subjects, which may be a mechanism by which depression is a significant risk factor for ischemic heart and cerebrovascular disease and/or mortality after myocardial infarction.
Response to injury and atherogenesis.
The studies point to the key role of the platelet in the stimulation of intimal smooth muscle proliferation that leads to the development of lesions of atherosclerosis.
Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide.
- J. Harlan, J. Levine, K. Callahan, B. Schwartz, L. Harker
- Biology, ChemistryJournal of Clinical Investigation
- 1 March 1984
It is concluded that the glutathione redox cycle plays an important role as an endogenous antioxidant defense mechanism in cultured endothelial cells.
Kinetics of the formed elements of human blood.
In this review the turnover of red cells, granulocytes, and platelets is exammed under basal and stimulated conditions and the number of cells and time spent in each developmental stage and the techniques whereby these may be measured are given.