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Iron and neurodegeneration in the multiple sclerosis brain
This study focused on nonheme iron distribution and the expression of the iron‐related proteins ferritin, hephaestin, and ceruloplasmin in relation to oxidative damage in the brain tissue of 33 MS and 30 control cases. Expand
Oxidative damage in multiple sclerosis lesions
The data suggest profound oxidative injury of oligodendrocytes and neurons to be associated with active demyelination and axonal or neuronal injury in multiple sclerosis. Expand
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury
The data suggest that the inflammation-associated oxidative burst in activated microglia and macrophages plays an important role in demyelination and free radical-mediated tissue injury in the pathogenesis of multiple sclerosis. Expand
The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain
A topographic map of the frequency with which different brain regions are affected by demyelination and neurodegeneration is provided, and it is shown that demyelsinations involve inflammatory as well as vascular changes. Expand
Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron
Both focal lesions as well as diffuse neurodegeneration in the deep grey matter appeared to contribute to the neurological disabilities of MS patients. Expand
Inflammation, Iron, Energy Failure, and Oxidative Stress in the Pathogenesis of Multiple Sclerosis
  • L. Haider
  • Biology, Medicine
  • Oxidative medicine and cellular longevity
  • 27 May 2015
In the present review, the different sources of oxidative stress and their relationships to patients with multiple sclerosis considering tissue injury mechanisms and clinical aspects have been discussed. Expand
Disease-specific molecular events in cortical multiple sclerosis lesions
Cortical lesions constitute an important part of multiple sclerosis pathology. Although inflammation appears to play a role in their formation, the mechanisms leading to demyelination andExpand
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models
The study shows that oxidative injury and its triggering mechanisms diverge in different models of rodent central nervous system inflammation. Expand
Let's agree to disagree: learning highly debatable multirater labelling
This work investigates joint models of individual rater behaviour and multirater consensus in a deep learning setting, and applies it to a brain lesion object-detection task, showing that jointly modelling both individual and consensus estimates leads to significant improvements in performance. Expand
In vivo imaging of chronic active lesions in multiple sclerosis.
The literature on imaging of chronic active lesion in MS is reviewed, focussing on 'slowly expanding lesions' (SELs), detected by volumetric longitudinal magnetic resonance imaging (MRI) and 'rim-positive' lesions, identified by susceptibility iron-sensitive MRI. Expand