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Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids.
Blood glucose levels fall because hepatic glucose output fails to keep up with augmented glucose utilization by the exercising legs, and augmented secretion of glucagon may play an important role in the metabolic adaptation to prolonged exercise by its stimulatory influence on hepatic glycogenolysis and gluconeogenesis. Expand
Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients.
Investigating mitochondrial function in selected depressed patients in search of an aetiological or pathophysiological factor common to both depression and physical symptoms suggested that mitochondrial dysfunction is associated with vulnerability to psychopathology in this selected patient group. Expand
Utilization of blood‐borne and intramuscular substrates during continuous and intermittent exercise in man.
The metabolic response to intermittent exercise was found to be similar to that found in continuous exercise with approximately the same average power output and oxygen uptake, which indicates that some factor in the intermediary metabolism functions as a regulator retarding glycolysis and favouring lipid utilization and an aerobic energy release in intermittent exercise. Expand
Influence of glucose and fructose ingestion on the capacity for long-term exercise in well-trained men.
Intermittent glucose ingestion during prolonged, heavy bicycle exercise postpones exhaustion and exerts a glycogen-conserving effect in the working muscles, and fructose ingestion during exercise maintains the glucose concentration at the basal level but fails to influence either muscle glycogen degradation or endurance performance. Expand
Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus.
The inter-organ flux of substrates after a protein-rich meal was studied in seven healthy subjects and in eight patients, with diabetes mellitus, and there was a large amino acid release from the splanchnic bed predominantly involving the branched chain amino acids. Expand
Influence of lactate infusion on glucose and FFA metabolism in man.
The fractional uptake of lactate by the leg, the splanchnic region, and the forearm decreased during the course of the infusion, and sodium L(+)-lactate levels were 3 to 5 mmol/l during the infusion. Expand
Measurement of ATP production and respiratory chain enzyme activities in mitochondria isolated from small muscle biopsy samples.
It is concluded that the set of methods suitable for diagnosis of mitochondrial disorders in adults and small children, including determination of the mitochondrial ATP production rate (MAPR) and the activities of the respiratory chain complexes I, I+III, II-III, and IV and citrate synthase, are suitable. Expand
Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus.
Exercise in diabetic patients with mild ketosis is associated with a rise in blood glucose and FFA levels as well as augmented splanchnic production and peripheral uptake of ketone bodies and is concluded that glucose uptake by exercising muscle in hyperglycemic diabetics is no different from that of controls. Expand
A comparison of the effects of intravenous infusion of individual branched-chain amino acids on blood amino acid levels in man.
A mixed branched-chain amino acid solution with leucine as its main constituent seems to be the best alternative in the treatment of patients with hepatic cirrhosis and encephalopathy. Expand
The distribution of amino acids between plasma and erythrocytes.
Amino acid concentrations were determined in whole blood, plasma and washed erythrocytes from a group of healthy subjects. A comparison between the erythrocyte concentrations calculated from wholeExpand