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Growth, viral production and metabolism of a Helicoverpa zea cell line in serum-free culture
Insect cell cultures have been extensively utilised for means of production for heterologous proteins and biopesticides. Spodoptera frugiperda (Sf9) and Trichoplusia ni (High Five™) cell lines haveExpand
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Modular engineering of a microbially-produced viral capsomere vaccine for influenza
Faster and cheaper vaccine manufacture based on modern technologies is increasingly needed to effectively mitigate the burden of disease caused by highly contagious and mutagenic pathogens, such asExpand
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The economics of virus-like particle and capsomere vaccines
Effective control of infectious diseases relies on new vaccine technologies that can quicken and broaden vaccine delivery. Novel modular virus-like particle (VLP) and capsomere technologies have beenExpand
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Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccines
Virus-like particle (VLP) vaccines are emerging as an exciting platform for the delivery of antigenic modules to enable engineering of desirable immunological outcomes, both in therapeutic andExpand
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Sensitivity of Helicoverpa armigera nucleopolyhedrovirus polyhedra to sodium dodecyl sulfate
Sodium dodecyl sulfate (SDS) is commonly used to extract polyhedra from infected cells and diseased dead larval tissues. It was found, however, that 80% of Helicoverpa armigera nucleopolyhedrovirusExpand
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Synthetic biology design to display an 18 kDa rotavirus large antigen on a modular virus-like particle.
Virus-like particles are an established class of commercial vaccine possessing excellent function and proven stability. Exciting developments made possible by modern tools of synthetic biology hasExpand
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A rapid and simple screening method to identify conditions for enhanced stability of modular vaccine candidates
Virus-like particles (VLPs) and capsomere subunits have been developed as safe and effective vaccine candidates in the fight against infectious diseases. These bioengineered structures are suitableExpand
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The Importance of Cholesterol for Insect Cell Growth and Baculovirus Production
Cholesterol is believed to be an important component for insect cell culture in serum-free cultures to maintain good insect cell growth and to obtain good production of baculoviruses or recombinantExpand
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Virus-like particle bioprocessing: challenges and opportunities
Linda HL Lua University Protein Expression Facility, The University of Queensland, St Lucia QLD 4072, Australia “ advances in the design and manufacture of structured materials will continue to seeExpand
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