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Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highlyExpand
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A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB).Expand
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Is lactate a volume transmitter of metabolic states of the brain?
We present the perspective that lactate is a volume transmitter of cellular signals in brain that acutely and chronically regulate the energy metabolism of large neuronal ensembles. From thisExpand
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  • Open Access
The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain.
We have proposed that lactate is a "volume transmitter" in the brain and underpinned this by showing that the lactate receptor, G-protein-coupled receptor 81 (GPR81, also known as HCA1 or HCAR1),Expand
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Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP
Besides being a neuronal fuel, L-lactate is also a signal in the brain. Whether extracellular L-lactate affects brain metabolism, in particular astrocytes, abundant neuroglial cells, which produceExpand
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  • Open Access
Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease
In retina, like in brain, lactate equilibrates across cell membranes via monocarboxylate transporters and in the extracellular space by diffusion, forming a basis for the action of lactate as aExpand
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Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure.
Cardiac mitochondrial dysfunction has been implicated in heart failure of diverse etiologies. Generalized mitochondrial disease also leads to cardiomyopathy with various clinical manifestations.Expand
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  • Open Access
Monocarboxylate transport matters.
The liver makes ketone bodies (3-hydroxybutyrate, acetoacetate, and acetone, the breakdown product of acetoacetate) from fat when intracellular glucose is in short supply — for example, in starvationExpand
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  • Open Access
Increased expression of monocarboxylate transporter 1 after acute ischemia of isolated, perfused mouse hearts.
AIMS Lactate is transported by stereo-specific, pH-dependent monocarboxylate transporters (MCTs), of which MCT1 is expressed in abundance in rodent and human hearts. This study investigated theExpand
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Disturbed mitochondrial function restricts glutamate uptake in the human Müller glia cell line, MIO-M1.
Using the human Müller cell line, MIO-M1, the aim was to study the impact of mitochondrial inhibition in Müller glia through antimycin A treatment. MIO-M1 cell survival, levels of released lactate,Expand
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