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Obesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic Syndrome
The intimate interplay between immune system, metabolism, and gut microbiota plays an important role in controlling metabolic homeostasis and possible obesity development. Obesity involves impairmentExpand
Ouabain Modulates Zymosan-Induced Peritonitis in Mice
Ouabain, a potent inhibitor of the Na+, K+-ATPase, was identified as an endogenous substance. Recently, ouabain was shown to affect various immunological processes. We have previously demonstratedExpand
Ouabain attenuates ovalbumin-induced airway inflammation
PurposeOuabain, an Na+/K+-ATPase inhibitor hormone, presents immunomodulatory actions, including anti-inflammatory effect on acute inflammation models.MethodsIn the present study, the effect ofExpand
Warifteine and methylwarifteine inhibited the type 2 immune response on combined allergic rhinitis and asthma syndrome (CARAS) experimental model through NF-кB pathway.
CARAS is an airway inflammation of allergic individuals, with a type 2 immune response. The pharmacotherapy is based on drugs with relevant side effects. Thus, the goal of this study evaluated theExpand
Milonine, an Alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae) Inhibits Histamine Release of Activated Mast Cells
Milonine is an alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae), a plant used in the northeast of Brazil to treat allergies such as asthma, rhinitis, and other conditions. Previously,Expand
Corrigendum: Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
[This corrects the article on p. 895 in vol. 8, PMID: 29176951.].
Antinociceptive and Anti-Inflammatory Activity from Algae of the Genus Caulerpa
Marine natural products have been the focus of discovery for new products of chemical and pharmacological interest. The aim of this study was to evaluate the antinociceptive activity of theExpand
Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine
In previous works we showed that oral administration of caulerpine, a bisindole alkaloid isolated from algae of the genus Caulerpa, produced antinociception when assessed in chemical and thermalExpand
The Antinociceptive and Anti-Inflammatory Activities of Aspidosperma tomentosum (Apocynaceae)
We investigated the antinociceptive and anti-inflammatory activities of the crude ethanolic extract (CEE), its fractions, and the flavonoid isorhamnetin from Aspidosperma tomentosum using models ofExpand
Spasmolytic Effect of Caulerpine Involves Blockade of Ca2+ Influx on Guinea Pig Ileum
In this work, we investigated the spasmolytic effect of caulerpine, a bisindole alkaloid isolated from marine algae of the Caulerpa genus, on guinea pig ileum. Our findings indicated that caulerpineExpand