Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells.
- T. Ichimura, E. V. Asseldonk, B. Humphreys, L. Gunaratnam, J. Duffield, J. Bonventre
- BiologyJournal of Clinical Investigation
- 1 May 2008
KIM-1 is the first nonmyeloid phosphatidylserine receptor identified to the authors' knowledge that transforms epithelial cells into semiprofessional phagocytes and was directly responsible for phagocytosis in cultured primary rat tubule epithel cells and also porcine and canine epithelial cell lines.
Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells.
- L. Gunaratnam, M. Morley, Stephen Lee
- BiologyJournal of Biological Chemistry
- 2003
It is reported that HIF plays a central role in promoting unregulated growth of VHL(-/-) RCC cells by activating the transforming growth factor-alpha (TGF-alpha)/epidermal growth factor receptor (EGF-R) pathway, and suggests that it might be involved in oncogenesis to a much higher extent than previously appreciated.
HIF activation by pH-dependent nucleolar sequestration of VHL
- Karim Mekhail, L. Gunaratnam, Marie-Ève Bonicalzi, Stephen Lee
- BiologyNature Cell Biology
- 1 July 2004
It is demonstrated that hypoxia induction or normoxic acidosis can neutralize the function of VHL by triggering its nucleolar sequestration, a regulatory mechanism of protein function that is observed rarely and which enables HIF to evade destruction in the presence of oxygen and activate its target genes.
Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
- A. Franovic, L. Gunaratnam, K. Smith, I. Robert, D. Patten, Stephen Lee
- BiologyProceedings of the National Academy of Sciences
- 7 August 2007
Evidence is provided that overexpression of wild-type EGFR can be induced by the hypoxic microenvironment and activation of hypoxia-inducible factor 2-α (HIF2α) in the core of solid tumors, and a role for HIF2 α activation in the regulation of EGFR protein synthesis is highlighted.
HIF in kidney disease and development.
- L. Gunaratnam, J. Bonventre
- Biology, MedicineJournal of the American Society of Nephrology
- 1 September 2009
The mechanisms of oxygen sensing in renal cells are discussed and the role of hypoxia and HIF activation under physiologic conditions and in renal development as well as in acute and chronic kidney diseases are highlighted.
Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice
- S. Arai, Kento Kitada, T. Miyazaki
- Biology, MedicineNature Network Boston
- 4 January 2016
It is shown that the apoptosis inhibitor of macrophage (AIM) protein on intraluminal debris interacts with kidney injury molecule (KIM)-1 and promotes recovery from AKI and provides a basis for the development of potentially novel therapies for AKI.
Regulation of ubiquitin ligase dynamics by the nucleolus
- Karim Mekhail, M. Khacho, A. Carrigan, R. Hache, L. Gunaratnam, Stephen Lee
- BiologyJournal of Cell Biology
- 29 August 2005
Data shown here provide the first evidence that cells have evolved a mechanism to regulate molecular networks by reversibly switching proteins between a mobile and static state.
Hypoxia Inducible Factor Activates the Transforming Growth Factor-α/Epidermal Growth Factor Receptor Growth Stimulatory Pathway in VHL-/- Renal Cell Carcinoma Cells*
- L. Gunaratnam, M. Morley, Stephen Lee
- BiologyJournal of Biological Chemistry
- 7 November 2003
It is reported that HIF plays a central role in promoting unregulated growth of VHL-/- RCC cells by activating the transforming growth factor-α (TGF-α)/epidermal growth factor receptor (EGF-R) pathway, and suggests that it might be involved in oncogenesis to a much higher extent than previously appreciated.
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.
- K. Smith, L. Gunaratnam, M. Morley, A. Franovic, Karim Mekhail, Stephen Lee
- BiologyCancer Research
- 15 June 2005
Data identify EGFR as a critical determinant of HIF-2alpha-dependent tumorigenesis and show at the molecular level that EGFR remains a credible target for therapeutic strategies against VHL-/- renal carcinoma.
Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis.
- R. Gandhi, James Yi, L. Gunaratnam
- BiologyAJP - Renal Physiology
- 15 July 2014
The results suggest that K IM-1 shedding is accelerated by worsening cellular injury, and excess soluble KIM-1 competitively inhibits efferocytosis, which may be important in AKI when there is severe cellular injury.
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