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Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer.
Vascular endothelial growth factors (VEGFs) are critical regulators of vascular and lymphatic function during development, in health and in disease. There are five mammalian VEGF ligands and threeExpand
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VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
The vascular endothelial growth factors VEGFA and VEGFC are crucial regulators of vascular development. They exert their effects by dimerization and activation of the cognate receptors VEGFR2 andExpand
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VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd
VEGFR2 activates c-Src and induces vascular permeability by binding to the adaptor protein TSAd
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Tetraspanin CD63 Promotes Vascular Endothelial Growth Factor Receptor 2-β1 Integrin Complex Formation, Thereby Regulating Activation and Downstream Signaling in Endothelial Cells in Vitro and in Vivo*
Background: The tetraspanin CD63 is known to regulate protein trafficking, leukocyte recruitment, and adhesion processes. Results: Silencing of CD63 disrupts complex formation between β1 integrin andExpand
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Signal transduction by vascular endothelial growth factor receptors.
VEGFs (vascular endothelial growth factors) control vascular development during embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There are five related mammalianExpand
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Induction of erythroid differentiation of human K562 cells by cisplatin analogs.
Human leukemic K562 cells can be induced in vitro to erythroid differentiation by a variety of chemical compounds, including hemin, butyric acid, 5-azacytidine, and cytosine arabinoside.Expand
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Calcitonin receptor-like receptor guides arterial differentiation in zebrafish.
The calcitonin receptor-like receptor (crlr) is a major endothelial cell receptor for adrenomedullin, a peptide vasodilator involved in cardiovascular development, homeostasis, and disease. Here, weExpand
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Phenotypic behavior of C2C12 myoblasts upon expression of the dystrophy‐related caveolin‐3 P104L and TFT mutants
Caveolin‐3 (Cav‐3) is the main scaffolding protein present in myofiber caveolae. We transfected C2C12 myoblasts with dominant negative forms of Cav‐3, P104L or ΔTFT, respectively, which cause theExpand
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Ascorbic acid rescues cardiomyocyte development in Fgfr1(-/-) murine embryonic stem cells.
Fibroblast growth factor receptor 1 (Fgfr1) gene knockout impairs cardiomyocyte differentiation in murine embryonic stem cells (mESC). Here, various chemical compounds able to enhance cardiomyocyteExpand
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