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Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway
Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53Expand
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Structure of the CED-4–CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
Interplay among four genes—egl-1, ced-9, ced-4 and ced-3—controls the onset of programmed cell death in the nematode Caenorhabditis elegans. Activation of the cell-killing protease CED-3 requiresExpand
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Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.
The recognition of the phosphorylated BACH1 helicase by the BRCA1 C-terminal (BRCT) repeats is important to the tumor suppressor function of BRCA1. Here we report the crystal structure of the BRCTExpand
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Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.
Programmed cell death in Caenorhabditis elegans is initiated by the binding of EGL-1 to CED-9, which disrupts the CED-4/CED-9 complex and allows CED-4 to activate the cell-killing caspase CED-3. HereExpand
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Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis
Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate hostExpand
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Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State
The intracellular pathogen Legionella pneumophila hijacks the endoplasmic reticulum (ER)-derived vesicles to create an organelle designated Legionella-containing vacuole (LCV) required for bacterialExpand
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Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry
  • Zhuoru Wu, N. Yan, +7 authors Y. Shi
  • Biology, Medicine
  • Nature Structural &Molecular Biology
  • 11 December 2006
Intramembrane proteolysis regulates diverse biological processes. Cleavage of substrate peptide bonds within the membrane bilayer is catalyzed by integral membrane proteases. Here we report theExpand
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Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
STING functions as both an adaptor protein signaling cytoplasmic double-stranded DNA and a direct immunosensor of cyclic diguanylate monophosphate (c-di-GMP). The crystal structures of the C-terminalExpand
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C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1
Externalization of phosphatidylserine, which is normally restricted to the inner leaflet of plasma membrane, is a hallmark of mammalian apoptosis. It is not known what activates and mediates theExpand
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Crystal Structure and Biochemical Features of EfeB/YcdB from Escherichia coli O157
  • Xiuhua Liu, Q. Du, +6 authors L. Gu
  • Medicine, Chemistry
  • The Journal of Biological Chemistry
  • 15 February 2011
EfeB/YcdB is a member of the dye-decolorizing peroxidase (DyP) protein family. A recent study has shown that this protein can extract iron from heme without breaking the tetrapyrrole ring. We reportExpand
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