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Double-blind controlled trial of the therapeutic effects of prostacyclin in patients with completed ischaemic stroke.
In a pilot study, 26 patients with acute completed strokes (48 hours to 5 days after cerebral infarction) were randomly assigned to the prostacyclin (PGI2) or placebo groups. PGI2 sodium saltExpand
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L-arginine--substrate for no synthesis--its beneficial effects in therapy of patients with peripheral arterial disease: comparison with placebo-preliminary results.
Intravenous infusions of L-arginine (L-ARG) and placebo (saline) resulted in improvement of clinical assessments, statistically significant after L-ARG but not after saline. Results of laboratoryExpand
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Treatment of peripheral vascular disease with misoprostol (Cytotec): a pilot study.
Misoprostol, the oral analogue of alprostadil, was used to treat 20 patients (aged 40-60 years) with peripheral arterial disease (PAD) according to Fontaine's classification at stages IIa and IIb.Expand
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[Use of prostacyclin in patients with ischemic stroke. A double-blind method II].
Thirty patients with acute ischaemic stroke were allocated randomly into a group treated with prostacyclin and a group receiving placebo. The treatment was started 24 to 72 hours after the onset ofExpand
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Bencyclane - a new aspect of the mechanism of action in patients with peripheral arterial occlusive disease. Open-label, prospective, randomized trial
Wstep . Bencyklan wywiera korzystny efekt terapeutyczny u pacjentow ze schorzeniami naczyn obwodowych, jednak mechanizmu jego dzialania calkowicie nie wyjaśniono. Podjeto probe wyjaśnienia mechanizmuExpand
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Misoprostol (cytotec) in the treatment of peripheral ischaemic disease.
The stable prostacyclin analogue-iloprost and prostaglandin E1 (Alprostadil) showed a beneficial effect on activated platelets and leukocytes, and thrombocyte and leukocyte vessel interaction andExpand
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Misoprostol as agonist of IP2 receptor.
Fourteen patients with peripheral vascular disease received 200 microg of misoprostol 3 times a day during one month. The therapy with misoprostol caused clinical and biochemical improvement in allExpand
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The role of prostaglandin E2 in duodenal mucosa of healthy subjects and duodenal ulcer patients.
The distribution of the mucosal PGE2-generating capacity was bioassayed in the duodenum of 17 patients with duodenal ulcer (age range 20-58 years), and in 17 subjects (age range 21-57 years) who didExpand
[Use of nitrendipine in treating patients with obliterative atherosclerosis of arteries in the lower extremities].
Twenty patients with obliterative atherosclerosis in the lower extremities arteries (Fontaine's stage II) were treated with nitrendipine (Bayotensin) given in the dose of 20 mg daily for 6 weeks.Expand