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Double-blind controlled trial of the therapeutic effects of prostacyclin in patients with completed ischaemic stroke.
In a pilot study, 26 patients with acute completed strokes (48 hours to 5 days after cerebral infarction) were randomly assigned to the prostacyclin (PGI2) or placebo groups. PGI2 sodium salt… Expand
L-arginine--substrate for no synthesis--its beneficial effects in therapy of patients with peripheral arterial disease: comparison with placebo-preliminary results.
- M. Slawinski, L. Grodzińska, E. Kostka-Trąbka, K. Bieroń, A. Goszcz, R. Gryglewski
- Acta physiologica Hungarica
Intravenous infusions of L-arginine (L-ARG) and placebo (saline) resulted in improvement of clinical assessments, statistically significant after L-ARG but not after saline. Results of laboratory… Expand
Treatment of peripheral vascular disease with misoprostol (Cytotec): a pilot study.
- A. Goszcz, L. Grodzińska, +4 authors W. Ochmański
- Methods and findings in experimental and clinical…
- 1 June 1998
Misoprostol, the oral analogue of alprostadil, was used to treat 20 patients (aged 40-60 years) with peripheral arterial disease (PAD) according to Fontaine's classification at stages IIa and IIb.… Expand
[Use of prostacyclin in patients with ischemic stroke. A double-blind method II].
- J. Huczyński, R. Gryglewski, +7 authors A. Kędzior
- Neurologia i neurochirurgia polska
- 1 July 1988
Thirty patients with acute ischaemic stroke were allocated randomly into a group treated with prostacyclin and a group receiving placebo. The treatment was started 24 to 72 hours after the onset of… Expand
Bencyclane - a new aspect of the mechanism of action in patients with peripheral arterial occlusive disease. Open-label, prospective, randomized trial
Wstep . Bencyklan wywiera korzystny efekt terapeutyczny u pacjentow ze schorzeniami naczyn obwodowych, jednak mechanizmu jego dzialania calkowicie nie wyjaśniono. Podjeto probe wyjaśnienia mechanizmu… Expand
[Prostacyclin in treatment of peripheral vascular disease of lower extremities (author's transl)].
Misoprostol (cytotec) in the treatment of peripheral ischaemic disease.
- A. Goszcz, L. Grodzińska, E. Kostka-Trebka, K. Bieroń, M. Slawinski, R. Jachym
- Acta physiologica Hungarica
The stable prostacyclin analogue-iloprost and prostaglandin E1 (Alprostadil) showed a beneficial effect on activated platelets and leukocytes, and thrombocyte and leukocyte vessel interaction and… Expand
Misoprostol as agonist of IP2 receptor.
- A. Goszcz, K. Bieroń, L. Grodzińska
- Journal of physiology and pharmacology : an…
- 1 December 2002
Fourteen patients with peripheral vascular disease received 200 microg of misoprostol 3 times a day during one month. The therapy with misoprostol caused clinical and biochemical improvement in all… Expand
The role of prostaglandin E2 in duodenal mucosa of healthy subjects and duodenal ulcer patients.
- M. Basista, S. Bednarz, K. Rembiasz, L. Grodzińska, E. Kostka-Trąbka
- 1 December 1986
The distribution of the mucosal PGE2-generating capacity was bioassayed in the duodenum of 17 patients with duodenal ulcer (age range 20-58 years), and in 17 subjects (age range 21-57 years) who did… Expand
[Use of nitrendipine in treating patients with obliterative atherosclerosis of arteries in the lower extremities].
- L. Grodzińska, E. Kostka-Trąbka, M. Basista, K. Bieroń, M. Sławiński, E. Telesz
- Polski tygodnik lekarski
- 5 August 1991
Twenty patients with obliterative atherosclerosis in the lower extremities arteries (Fontaine's stage II) were treated with nitrendipine (Bayotensin) given in the dose of 20 mg daily for 6 weeks.… Expand