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Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation.
TLDR
Induction of LTP increased the phosphorus-32 labeling of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-Rs), which mediate rapid excitatory synaptic transmission and provides a postsynaptic molecular mechanism for synaptic plasticity. Expand
PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit
TLDR
These features of the Drosophila sleep circuit, GABAergic control of onset and maintenance as well as peptidergic control of arousal, support the idea that features of sleep-circuit architecture aswell as the mechanisms governing the behavioral transitions between sleep and wake are conserved between mammals and insects. Expand
Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception
TLDR
It is shown that fly and mosquito TRPA1 orthologues are molecular sensors of electrophiles, using a mechanism conserved with vertebrate TRPA 1s, and proposed that human pain perception relies on an ancient chemical sensor conserved across ∼500 million years of animal evolution. Expand
Regulation of DLG Localization at Synapses by CaMKII-Dependent Phosphorylation
TLDR
It is proposed that CaMKII-dependent DLG phosphorylation regulates the association of DLG with the synaptic complex during development and plasticity, thus providing a link between synaptic activity and structure. Expand
Generalization of Courtship Learning in Drosophila Is Mediated by cis-Vaccenyl Acetate
TLDR
It is shown that the volatile aversive pheromone that leads to generalized learning with mated females is (Z)-11-octadecenyl acetate (cis-vaccenylacetate, cVA), and transfer of cVA to females during mating may be part of the male's strategy to suppress reproduction by competing males. Expand
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain
TLDR
It is shown that the unknown function of the 10 PDF-containing large ventral lateral neurons (l-LNvs) of the Drosophila circadian brain network and show here that these cells function in light-dependent arousal, indicating that the circadian photoresponse is a network property and therefore non-cell-autonomous. Expand
Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila
TLDR
It is shown that sleep is regulated by GABA in Drosophila and that a mutant GABAA receptor, RdlA302S, specifically decreases sleep latency, and this results suggest that this biophysical property of the channel, specifically channel desensitization, underlies the regulation of sleep latency in flies. Expand
Temporal dynamics of neuronal activation by Channelrhodopsin-2 and TRPA1 determine behavioral output in Drosophila larvae.
TLDR
The results suggest that dTRPA1 may be particularly useful for researchers interested in activating fly neural circuits over long time scales, and understanding the cellular effects of these genetic tools and their temporal dynamics is important for the design and interpretation of behavioral experiments. Expand
Electrophysiological and morphological characterization of identified motor neurons in the Drosophila third instar larva central nervous system.
TLDR
Dye fills and electrophysiological recordings are used to identify and characterize a cluster of motor neurons in the third instar larval ventral ganglion and explore the cellular substrates of neural and locomotor behavior in an intact system. Expand
A gustatory receptor paralog controls rapid warmth avoidance in Drosophila
TLDR
A new type of thermosensory molecule is revealed and a functional distinction between peripheral and internal warmth sensors in this tiny ectotherm reminiscent of thermoregulatory systems in larger, endothermic animals is uncovered. Expand
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