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A Double‐Blind, Randomized, Placebo‐Controlled Trial of Macrolide in the Treatment of Chronic Rhinosinusitis
Objectives: The antiinflammatory effect of macrolide antibiotics has been well‐established, as has their role in the treatment of certain disorders of chronic airway inflammation. Several studiesExpand
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Inhalation of LPS induces inflammatory airway responses mimicking characteristics of chronic obstructive pulmonary disease
Aim:  Inhalation of lipopolysaccharide (LPS) produces both systemic and pulmonary inflammatory responses. The aim of this study was to further characterize the response to LPS in order to develop aExpand
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Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis
BackgroundInteractions between Th1 and Th2 immune responses are of importance to the onset and development of allergic disorders. A Toll-like receptor 7 agonist such as AZD8848 may have potential asExpand
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Immunomodulatory nanoparticles as adjuvants and allergen-delivery system to human dendritic cells: Implications for specific immunotherapy.
Novel adjuvants and antigen-delivery systems with immunomodulatory properties that shift the allergenic Th2 response towards a Th1 or regulatory T cell response are desired for allergen-specificExpand
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Clinical efficacy and pharmacokinetic profiles of intranasal and oral cetirizine in a repeated allergen challenge model of allergic rhinitis.
BACKGROUND Intranasal and oral antihistamines are effective in treating allergic rhinitis. Studies comparing these routes of administration of an antihistamine regarding efficacy and pharmacokineticExpand
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Symptoms and endoscopic findings in the diagnosis of gastroesophageal reflux disease.
Two hundred and twenty patients with symptoms suggestive of pathologic gastroesophageal reflux were investigated to elucidate the ability of symptoms and endoscopic findings in establishing aExpand
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The use of the nose to study the inflammatory response of the respiratory tract.
There are several reasons for investigating inflammatory responses in the nasal mucosa. There is evidence for an increasing frequency of allergic rhinitis,' and nasal symptoms may be an early sign ofExpand
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Allergen challenge-induced entry of alpha 2-macroglobulin and tryptase into human nasal and bronchial airways.
BACKGROUND Microvascular-epithelial exudation of bulk plasma may characterize inflammatory airway diseases. This study compares the acute allergen challenge-induced mast cell and exudative responsesExpand
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Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways.
Cytotoxic eosinophil granule proteins are considered important in the pathogenesis of allergic airway diseases such as rhinitis and asthma. To explore the cellular mechanisms behind eosinophilExpand
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Degranulation patterns of eosinophil granulocytes as determinants of eosinophil driven disease
BACKGROUND Degranulation of eosinophils in target tissues is considered a key pathogenic event in major chronic eosinophilic diseases. However, because of a lack of appropriate methods, little isExpand
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