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A Double‐Blind, Randomized, Placebo‐Controlled Trial of Macrolide in the Treatment of Chronic Rhinosinusitis
The antiinflammatory effect of macrolide antibiotics has been well‐established, as has their role in the treatment of certain disorders of chronic airway inflammation, but this effect has not been tested in a randomized, placebo‐controlled study.
Inhalation of LPS induces inflammatory airway responses mimicking characteristics of chronic obstructive pulmonary disease
This study characterized the response to LPS in order to develop a human model suitable for early testing of drug candidates developed for the treatment for chronic obstructive pulmonary disease (COPD).
Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways.
The nature and extent of the ECL and its product indicate that allergen-induced cytolysis is a primary and major mechanism for the release of eosinophil proteins in human allergic airway inflammation in vivo.
Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis
Repeated intranasal stimulation of Toll-like receptor 7 by AZD8848 was safe and produced a sustained reduction in the responsiveness to allergen in allergic rhinitis.
Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposure
It is demonstrated that the nasal mucosa in allergic rhinitis features moderately degranulated eosinophils already at nonsymptomatic baseline conditions, and the tissue deposition of eosInophil granule proteins is dramatically elevated through increased eos inophil numbers, together with markedly augmented degranulation of individual cells.
Symptoms and endoscopic findings in the diagnosis of gastroesophageal reflux disease.
It is concluded that it is difficult to establish a diagnosis of gastroesophageal reflux disease by patient history alone, that erythema at endoscopy correlates poorly with pathologic reflux, and thatReflux disease may be present even with normal endoscopic findings.
Immediate effect of topical budesonide on allergen challenge-induced nasal mucosal fluid levels of granulocyte-macrophage colony-stimulating factor and interleukin-5.
It is demonstrated that GM-CSF and IL-5 are induced in a nonsymptomatic, late phase response to nasal allergen challenge, and that this cytokine response is prevented by single dose budesonide pretreatment.