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Colorectal Neoplasia Differentially Expressed (CRNDE), a Novel Gene with Elevated Expression in Colorectal Adenomas and Adenocarcinomas.
TLDR
It is concluded that individual CRNDE transcripts show promise as tissue and plasma biomarkers, potentially exhibiting high sensitivity and specificity for colorectal adenomas and cancers.
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CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment
TLDR
It is suggested that CRNDE is a multifunctional lncRNA whose different splice forms provide specific functional scaffolds for regulatory complexes, such as the polycomb repressive complex 2 (PRC2) and CoREST chromatin-modifying complexes, whichCRNDE helps pilot to target genes.
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CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism.
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The X-ray Structure of a Hemipteran Ecdysone Receptor Ligand-binding Domain
TLDR
Evidence is presented indicating that much of the selectivity of the bisacylhydrazine insecticides can be studied at the level of their binding to purified ecdysone receptor ligand-binding domain (LBD) heterodimers.
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Role of insulin‐like growth factor binding protein‐3 in breast cancer cell growth
The mitogenic effects of insulin‐like growth factors (IGFs) are regulated by a family of insulin‐like growth factor binding proteins (IGFBPs). One member of this family, IGFBP‐3, mediates the…
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Proteinaceous adhesive secretions from insects, and in particular the egg attachment glue of Opodiphthera sp. moths.
Biochemical and electrophoretic screening of 29 adhesive secretions from Australian insects identified six types that appeared to consist largely of protein. Most were involved in terrestrial egg…
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Genetic reconstruction and functional analysis of the repeating lipoyl domains in the pyruvate dehydrogenase multienzyme complex of Escherichia coli.
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Ecdysone receptors: from the Ashburner model to structural biology.
TLDR
X-ray diffraction studies of the ligand-binding domain of the receptor are elucidating the specificity of receptor-ecdysteroid interactions, the selectivity of some environmentally friendly insecticides, the evolution of the EcR-USP heterodimer, and indeed Ashburner's classical biochemical evidence for the central role of the ecdysone receptor in his model.
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Characterization of a protein-based adhesive elastomer secreted by the Australian frog Notaden bennetti.
TLDR
In addition to compositional similarities with other biological adhesives and well-known elastomeric proteins, the circular dichroism spectrum of dissolved glue is almost identical to that for soluble elastin and electron and scanning probe microscopy images invite comparison with silk fibroins.
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Kinetics and specificity of reductive acylation of lipoyl domains from 2-oxo acid dehydrogenase multienzyme complexes.
TLDR
The results indicate the great improvement in the effectiveness of lipoic acid as a substrate for E1p that accompanies the attachment of the lipoyl group to a protein domain.
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