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Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol.
BACKGROUND The protein kinase C (PKC) family of serine/threonine-specific protein kinases is involved in many cellular processes, and the unregulated activation of PKC has been implicated inExpand
Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy.
BACKGROUND Taxol is a natural product produced by the Pacific yew, Taxus brevifolia, that has emerged as a prominent chemotherapeutic agent for the treatment of solid tumors. It binds toExpand
A novel cytotoxic macrolide, superstolide B, related to superstolide A, from the New Caledonian marine sponge Neosiphonia superstes.
The structure of a new cytotoxic macrolide, superstolide B [1], isolated from the deep water sponge Neosiphonia superstes, collected off New Caledonia, was elucidated mainly on the basis of nmr data.Expand
Neosiphoniamolide A, a novel cyclodepsipeptide, with antifungal activity from the marine sponge Neosiphonia superstes.
A novel cyclodepsipeptide, neosiphoniamolide A [1], has been isolated from the sponge Neosiphonia superstes. The structure of 1, which contains a 12-carbon hydroxy acid, glycine, valine, and aExpand