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Chapter 1: HPV in the etiology of human cancer.
TLDR
The causal role of human papillomavirus in all cancers of the uterine cervix has been firmly established biologically and epidemiologically and co-infection with Chlamydia trachomatis and herpes simplex virus type-2 have been identified as established cofactors. Expand
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
TLDR
It is found that the HPV 18 DNA is integrated into the cellular genome and is amplified in HeLa and 756 cells, and some of the transcripts are composed of HPV 18 and cellular sequences. Expand
A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.
TLDR
The data indicate that HPV 16 DNA prevails in malignant tumors, rendering an accidental contamination with papillomavirus DNA from adjacent papillomas rather unlikely, and suggests a dependence of HPV 16 replication on helper virus. Expand
A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.
TLDR
DNA of a new papillomavirus type was cloned from a cervical carcinoma biopsy and the data reveal that the DNA might be integrated into the host cell genome, which is tentatively proposed to be HPV 18. Expand
Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles
TLDR
The ability to generate preparative amounts of HPV16 L1 and L1-L2 VLP may have implications for the development of a serological assay to detect anti-HPV16 virion immune responses to conformational epitopes and for immunoprophylaxis against HPV16 infection. Expand
HPV in the etiology of human cancer
TLDR
Genetic and immunological host factors and viral factors other than type, such as variants of type, viral load and viral integration, are likely to be important but have not been clearly identified. Expand
TLR9 Expression and Function Is Abolished by the Cervical Cancer-Associated Human Papillomavirus Type 161
TLDR
A novel mechanism used by HPV16 to suppress the host immune response by deregulating the TLR9 transcript is revealed, providing evidence that abolishing innate responses may be a crucial step involved in the carcinogenic events mediated by HPVs. Expand
Bead-Based Multiplex Genotyping of Human Papillomaviruses
TLDR
Multiplex human papillomavirus genotyping (MPG), a quantitative and sensitive high-throughput procedure for the identification of multiple high- and low-risk genital HPV genotypes in a single reaction appears to be highly suitable for large-scale epidemiological studies and vaccination trials as well as for routine diagnostic purposes. Expand
Transcriptional regulation of the human papillomavirus‐16 E6‐E7 promoter by a keratinocyte‐dependent enhancer, and by viral E2 trans‐activator and repressor gene products: implications for cervical
TLDR
The keratinocyte‐dependent enhancer is likely to contribute to the epithelial cell tropism of HPV‐16, and may direct persistent E6‐E7 gene transcription in response to cellular factors in cervical carcinoma cells in which the viral E2 genes are inactive. Expand
Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers.
TLDR
The data support a genital origin of laryngeal papillomavirus infections and a possible role of this or related papillmavirus types in the induction of malignant genital tumors remains to be elucidated. Expand
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