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- Publications
- Influence
Multiphase composites with extremal bulk modulus
- L. Gibiansky, O. Sigmund
- Mathematics
- 1 March 2000
Abstract This paper is devoted to the analytical and numerical study of isotropic elastic composites made of three or more isotropic phases. The ranges of their effective bulk and shear moduli are… Expand
Variational principles for complex conductivity, viscoelasticity, and similar problems in media with complex moduli
- A. Cherkaev, L. Gibiansky
- Physics
- 1994
Linear processes in media with dissipation arising in conductivity, optics, viscoelasticity, etc. are considered. Time‐periodic fields in such media are described by linear differential equations for… Expand
Approximations of the target-mediated drug disposition model and identifiability of model parameters
- L. Gibiansky, E. Gibiansky, T. Kakkar, P. Ma
- Computer Science, Medicine
- Journal of Pharmacokinetics and Pharmacodynamics
- 13 November 2008
TLDR
Connection between the conductivity and bulk modulus of isotropic composite materials
- L. Gibiansky, S. Torquato
- Materials Science
- Proceedings of the Royal Society of London…
- 8 February 1996
Rigorous cross-property bounds that connect the effective electrical conductivity σ* and the effective bulk modulus K* of any isotropic two-phase composite are derived when the volume fractions of… Expand
Coupled estimates for the bulk and shear moduli of a two-dimensional isotropic elastic composite
- A. Cherkaev, L. Gibiansky
- Materials Science
- 1 May 1993
Abstract We improve the classical Hashin-Shtrikman and Walpole estimates of the effective properties for an isotropic mixture assembled from two isotropic elastic materials. The planar elasticity… Expand
The exact coupled bounds for effective tensors of electrical and magnetic properties of two-component two-dimensional composites
- A. Cherkaev, L. Gibiansky
- Materials Science
- 1992
Target-mediated drug disposition model: approximations, identifiability of model parameters and applications to the population pharmacokinetic–pharmacodynamic modeling of biologics
- L. Gibiansky, E. Gibiansky
- Medicine
- Expert opinion on drug metabolism & toxicology
- 22 June 2009
Models for drugs exhibiting target-mediated drug disposition (TMDD) describe biological processes in which drug-target binding significantly influences both pharmacodynamics (PD) and pharmacokinetics… Expand
Population Pharmacokinetics of Obinutuzumab (GA101) in Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin's Lymphoma and Exposure–Response in CLL
- E. Gibiansky, L. Gibiansky, D. Carlile, C. Jamois, V. Buchheit, N. Frey
- Medicine
- CPT: pharmacometrics & systems pharmacology
- 1 October 2014
Treatment regimens involving obinutuzumab (GA101) demonstrated increased efficacy to rituximab in clinical trials for non‐Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL). However, the… Expand
Population Pharmacokinetic Analysis of Denosumab in Patients with Bone Metastases from Solid Tumours
- L. Gibiansky, L. Sutjandra, +6 authors J. Pérez-Ruixo
- Medicine
- Clinical Pharmacokinetics
- 30 September 2012
Background and ObjectiveDenosumab (XGEVA®; AMG 162) is a fully human IgG2 monoclonal antibody, which binds to the receptor activator of nuclear factor K-B ligand (RANKL) and prevents terminal… Expand
Population PK and IgE Pharmacodynamic Analysis of a Fully Human Monoclonal Antibody Against IL4 Receptor
ABSTRACTPurposeFor AMG 317, a fully human monoclonal antibody to interleukin receptor IL-4Rα, we developed a population pharmacokinetic (PK) model by fitting data from four early phase clinical… Expand