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Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules
Polyglutamine expansion (polyQ) in the protein huntingtin is pathogenic and responsible for the neuronal toxicity associated with Huntington's disease (HD). Although wild-type huntingtin possessesExpand
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Prevalence and Seasonal Variations of Six Bee Viruses in Apis mellifera L. and Varroa destructor Mite Populations in France
ABSTRACT A survey of six bee viruses on a large geographic scale was undertaken by using seemingly healthy bee colonies and the PCR technique. Samples of adult bees and pupae were collected from 36Expand
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Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression
The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation, a keyExpand
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PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.
The programmed death-1 (PD-1) molecule is involved in peripheral tolerance and in the immune escape mechanisms during chronic viral infections and cancer. PD-1 interacts with two ligands, PD-L1 andExpand
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Quiescent neural stem cells exit dormancy upon alteration of GABAAR signaling following radiation damage.
Quiescent neural stem cells (NSCs) are considered the reservoir for adult neurogenesis, generating new neurons throughout life. Until now, their isolation has not been reported, which has hamperedExpand
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Seasonal prevalence of pathogens and parasites in the savannah honeybee (Apis mellifera scutellata).
The loss of Apis mellifera L. colonies in recent years has, in many regions of the world, been alarmingly high. No single cause has been identified for these losses, but the interactions betweenExpand
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Comparative analysis of deformed wing virus (DWV) RNA in Apis mellifera and Varroa destructor
L'etude des populations virales et de leur impact sur la sante des colonies d'abeilles (Apis mellifera) souffre du fait que differents virus infectent simultanement les colonies sans produire deExpand
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Preferential binding of a G-quadruplex ligand to human chromosome ends
The G-overhangs of telomeres are thought to adopt particular conformations, such as T-loops or G-quadruplexes. It has been suggested that G-quadruplex structures could be stabilized by specificExpand
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Radiation-induced mitotic catastrophe in PARG-deficient cells
Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in the regulation of chromatin structure, DNA metabolism, cell division and cell death. Through the hydrolysis ofExpand
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Localization of deformed wing virus infection in queen and drone Apis mellifera L
The distribution of deformed wing virus infection within the honey bee reproductive castes (queens, drones) was investigated by in situ hybridization and immunohistology from paraffin embeddedExpand
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