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Low-dose aspirin for the prevention of atherothrombosis.
This review considers the role of low-dose aspirin for the prevention of atherothrombosis, discussing the molecular mechanism of action of aspirin as well as clinical and epidemiologic studies ofExpand
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Acute and clinically relevant drug-induced liver injury: a population based case-control study.
AIMS To provide quantitative information about the absolute and relative risks of acute and clinically relevant drug-induced liver injury. METHODS We performed a population-based case-control studyExpand
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Risk factors and short-term mortality of venous thromboembolism diagnosed in the primary care setting in the United Kingdom.
BACKGROUND Venous thromboembolism (VTE) manifesting as deep vein thrombosis (DVT) and pulmonary embolism (PE) remains a common vascular disease with high mortality and morbidity. Our aim was to studyExpand
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Reduced Risk of Colorectal Cancer among Long-Term Users of Aspirin and Nonaspirin Nonsteroidal Antiinflammatory Drugs
Use of nonsteroidal antiinflammatory drugs (NSAIDs) has been associated with a reduced risk of colorectal cancer, but limited information is available on the effect of individual nonaspirin NSAIDs.Expand
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Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of
Guidelines and Expert Consensus Documents aim to present all the relevant evidence on a particular issue in order to help physicians to weigh the benefits and risks of a particular diagnostic orExpand
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Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population.
BACKGROUND Most epidemiological studies evaluating the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and acute renal failure (ARF) found an increased risk for developing ARF whileExpand
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Use of the UK General Practice Research Database for pharmacoepidemiology.
The last decade has seen a surge in the use of computerized health care data for pharmacoepidemiology. Of all European databases, the General Practice Research Database (GPRD) in the UK, has been theExpand
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Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease.
BACKGROUND & AIMS Bacterial intestinal infections have been implicated as a possible cause of exacerbation of inflammatory bowel disease (IBD). We explored the relationship between infectiousExpand
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Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population.
BACKGROUND & AIMS Traditional nonaspirin, nonsteroidal anti-inflammatory drugs (tNSAIDs) have been associated with a 3- to 5-fold increased risk in upper gastrointestinal complications (UGIC).Expand
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Inverse association between nonsteroidal anti-inflammatory drugs and prostate cancer.
BACKGROUND Prostate cancer is considered a major health problem in western countries. Promising results from observational studies on cancer at other sites fuelled the publication of several studiesExpand
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