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Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
In the present study we have investigated whether pharmacophore models may account for the activity and selectivity of the known cyclooxygenase-2 (COX-2) selective inhibitors of the phenylsulfonylExpand
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Rational modification of human synovial fluid phospholipase A2 inhibitors.
Mammalian nonpancreatic secretory phospholipase A2 (PLAz) splits the 2-acyl bond in 1,2-diacylpho~phatide.~ This enzyme has been found in high concentrations in the synovial fluid of patients withExpand
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Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity of ketoprofen analogues.
Molecular modeling studies performed on the two cyclooxygenase isozymes (COXs) suggest that active site hydration is crucial for understanding inhibitor selectivity. In this work, models have beenExpand
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Regulation of Intracellular pH in Rat Lactotrophs: Involvement of Anionic Exchangers.
Regulation of the intracellular pH (pHi) of normal rat lactotrophs was studied. As this cell type, cultured with 10% FCS, can achieve a relatively alkaline pHi (7.3–7.5), we investigated the presenceExpand
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Synthesis and thermal behaviour of morpholine complexes with cobalt (II) and manganese (II) thiocyanates
The 1 ∶ 4 complexes of cobalt (II) and manganese (II) thiocyanates with morpholine (Morph), [M(NCS)2(Morph)4] (M=Co, Mn), were prepared and studied by means of thermogravimetry, derivativeExpand
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