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Batzelladine alkaloids from the caribbean sponge Monanchora unguifera and the significant activities against HIV-1 and AIDS opportunistic infectious pathogens
Abstract Five new polycyclic guanidine alkaloids, 16β-hydroxycrambescidin 359 (1), batzelladines K, L, M, and N (2–5), along with the previously reported ptilomycalin A (6), crambescidine 800 (7),Expand
PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti‐tumour activity
BACKGROUND AND PURPOSE PM01183 is a new synthetic tetrahydroisoquinoline alkaloid that is currently in phase I clinical development for the treatment of solid tumours. In this study we haveExpand
Regulation of tau RNA Maturation by Thyroid Hormone Is Mediated by the Neural RNA-Binding Protein Musashi-1
The tau gene encodes a microtubule-associated protein expressed by neuronal and glial cells. Abnormal deposits of Tau protein are characteristic of several neurodegenerative disorders. Additionally,Expand
Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ
Aplidin™, a new antitumoural drug presently in phase II clinical trials, has shown both in vitro and in vivo activity against human cancer cells. Aplidin™ effectively inhibits cell viability byExpand
Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells
Irvalec is a marine-derived antitumor agent currently undergoing phase II clinical trials. In vitro, Irvalec induces a rapid loss of membrane integrity in tumor cells, accompanied of a significantExpand
AplidinTM Induces Apoptosis in Human Cancer Cells via Glutathione Depletion and Sustained Activation of the Epidermal Growth Factor Receptor, Src, JNK, and p38 MAPK*
We report that AplidinTM, a novel antitumor agent of marine origin presently undergoing Phase II clinical trials, induced growth arrest and apoptosis in human MDA-MB-231 breast cancer cells atExpand
Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.
Several pinacol derivatives of podophyllotoxins bearing different side chains and functions at C-7 were synthesized through reductive cross-coupling of podophyllotoxone and several aldehydes andExpand
Identification and localization of a nucleolin homologue in onion nucleoli.
A protein homologous to nucleolin, a major nucleolar protein with multifunctional features involved in pre-rRNA synthesis and early processing, has been identified and localized in situ in onion rootExpand
Dexamethasone Induces Lipocalin‐Type Prostaglandin D Synthase Gene Expression in Mouse Neuronal Cells
Lipocalin‐type prostaglandin (PG) D synthase (L‐PGDS) is responsible for the production of PGD2, the main PG in the CNS. PGD2 is an endogenous sleep inducer, and it is involved in the control of odorExpand
Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines.
Zalypsis is a new synthetic alkaloid tetrahydroisoquinoline antibiotic that has a reactive carbinolamine group. This functionality can lead to the formation of a covalent bond with the amino group ofExpand