• Publications
  • Influence
Merkel Cell Carcinoma: Epidemiology, Target, and Therapy
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin with a rising incidence. MCC has metastatic potential regardless the size of the primary tumor and a 5-year diseaseExpand
  • 75
  • 4
Upregulation of microRNA-524-5p enhances the cisplatin sensitivity of gastric cancer cells by modulating proliferation and metastasis via targeting SOX9
Cisplatin-based chemotherapy is the most commonly used treatment regimen for gastric cancer (GC), however, the resistance to cisplatin represents the key limitation for the therapeutic efficacy.Expand
  • 37
  • 4
  • PDF
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies
BACKGROUND. Monogenic IFN‐mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN response gene signature, inflammatory organ damage, and high mortality. We used theExpand
  • 140
  • 3
  • PDF
Subglottic secretion suction for preventing ventilator-associated pneumonia: an updated meta-analysis and trial sequential analysis
BackgroundPotential benefits of subglottic secretion suction for preventing ventilator-associated pneumonia (VAP) are not fully understood.MethodsWe searched Cochrane Central, PubMed, and EMBASE upExpand
  • 34
  • 3
IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma
Insulin-like growth factor (IGF) signaling is involved in oral squamous cell carcinoma (OSCC), but IGF-1 receptor (IGF-1R)-mediated intricate regulatory networks among molecular interactions andExpand
  • 39
  • 3
  • PDF
Protective effect of chemical stimulation of cerebellar fastigial nucleus on stress gastric mucosal injury in rats.
AIMS We investigated the protective effects of chemical stimulation of cerebellar fastigial nucleus (FN) on stress gastric mucosal injury (SGMI) and its possible neuro-regulatory mechanisms in rats.Expand
  • 15
  • 3
BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo.
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin currently with no cure. In this study, we have first demonstrated that c-Myc overexpression is common in MCC. ByExpand
  • 63
  • 2
  • PDF
PTENp1, a natural sponge of miR‐21, mediates PTEN expression to inhibit the proliferation of oral squamous cell carcinoma
PTENp1, non‐coding RNA (ncRNA) pseudogene, is involved in oral squamous cell carcinoma (OSCC). The precise effects mediated by PTENp1 transcripts within intricate regulatory networks involvingExpand
  • 45
  • 2
AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver
Our previous study found that thyroid-stimulating hormone promoted sterol regulatory element-binding protein-2 (SREBP-2) expression and suppressed AMP-activated protein kinase (AMPK) activity in theExpand
  • 36
  • 2
  • PDF
Exonic mutations of TSC2/TSC1 are common but not seen in all sporadic pulmonary lymphangioleiomyomatosis.
To the Editor: Pulmonary lymphangioleiomyomatosis (LAM) is a rare, progressive disease affecting almost exclusively women that is seen in both patients with tuberous sclerosis complex (TSC) andExpand
  • 50
  • 2
  • PDF