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Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage.
There is still controversy over whether analytical techniques currently in use are able to identify the level of damage to spermatozoa and large-scale studies should be conducted in different clinical settings to determine the effects of sperm DNA damage on the outcome of ART.
Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy.
A specific composition of phospholipids and a significant concentration of polyunsaturated fatty acids (PUFA) have been shown to be present in sperm membranes and Seminal plasma has a highly specialized scavenger system that defends the sperm membrane against lipoperoxidation.
Study of apoptotic DNA fragmentation in human spermatozoa.
The results suggest that apoptosis could be the final result of various pathologies and of a deregulation of spermatogenesis control systems.
Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial.
Fatty acid composition of spermatozoa and immature germ cells.
This study demonstrates that the human germ cell line can elongate and desaturate essential fatty acids and that the percentage of long-chain PUFA is correlated with the normal morphology of sperm cells.
Nuclear chromatin variations in human spermatozoa undergoing swim-up and cryopreservation evaluated by the flow cytometric sperm chromatin structure assay.
- M. Spanô, E. Cordelli, G. Leter, F. Lombardo, A. Lenzi, L. Gandini
- BiologyMolecular human reproduction
The results showed that post-rise spermatozoa represent a subpopulation characterized by a general improvement of the morphological (reduction of the percentage of abnormal forms and heads, increase of the green head sperm percentage) and kinetic parameters, indicative of optimal fertilizing ability.
The role of antioxidant therapy in the treatment of male infertility: an overview.
- F. Lombardo, A. Sansone, F. Romanelli, D. Paoli, L. Gandini, A. Lenzi
- BiologyAsian journal of andrology
- 20 June 2011
Since there is no linear correlation between sperm quality and pregnancy rates, an improvement in semen parameters should not be the sole outcome considered in studies of antioxidant therapies, and more multicentre, double-blind studies performed with the same criteria are necessary for an increased understanding of the effects of various antioxidants on fertility.
A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia.
Pesticide exposure and serum organochlorine residuals among testicular cancer patients and healthy controls
- F. Giannandrea, L. Gandini, D. Paoli, R. Turci, I. Figa-talamanca
- MedicineJournal of environmental science and health. Part…
- 8 September 2011
Findings give additional support to the results of previous research that suggest that some environmental exposures to OPs may be implicated in the pathogenesis of TC.
Testicular cancer and Hodgkin's disease: evaluation of semen quality.
Better semen quality was observed in patients with HD than in those with TC, and seems better than previous results reported in the literature.