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Mitochondrial membrane permeabilization in cell death.
Once MMP has been induced, it causes the release of catabolic hydrolases and activators of such enzymes (including those of caspases) from mitochondria, meaning that mitochondria coordinate the late stage of cellular demise.
Molecular mechanisms of necroptosis: an ordered cellular explosion
- P. Vandenabeele, L. Galluzzi, T. Berghe, G. Kroemer
- Biology, MedicineNature Reviews Molecular Cell Biology
- 1 October 2010
Evidence now reveals that necrosis can also occur in a regulated manner, and necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death.
Immunogenic cell death in cancer therapy.
- G. Kroemer, L. Galluzzi, O. Kepp, L. Zitvogel
- Biology, MedicineAnnual review of immunology
- 21 March 2013
It is postulate that ICD constitutes a prominent pathway for the activation of the immune system against cancer, which in turn determines the long-term success of anticancer therapies and its subversion by pathogens.
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
A functional classification of cell death subroutines is proposed that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic programmed cell death, regulated necrosis, autophagic cell death and mitotic catastrophe.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed.
Molecular mechanisms of cisplatin resistance
A systematic discussion of the mechanisms that account for the cisplatin-resistant phenotype of tumor cells are described and the development of chemosensitization strategies constitute a goal with important clinical implications.
Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
It is demonstrated that autophagy, which is often disabled in cancer, is dispensable for chemotherapy-induced cell death but required for its immunogenicity, and increased extracellular ATP concentrations improve the efficacy of antineoplastic chemotherapies when Autophagy is disabled.
Immunogenic cell death in cancer and infectious disease
- L. Galluzzi, A. Buqué, O. Kepp, L. Zitvogel, G. Kroemer
- BiologyNature Reviews Immunology
- 1 February 2017
Current knowledge on the mechanisms that underlie the activation of immune responses against dying cells and their pathophysiological relevance are reviewed.
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
A nonexhaustive comparison of methods to detect cell death with apoptotic or nonapoptotic morphologies, their advantages and pitfalls is provided and the importance of performing multiple, methodologically unrelated assays to quantify dying and dead cells is emphasized.
Targeting mitochondria for cancer therapy
The mitochondrial metabolism of cancer cells is deregulated owing to the use of glycolytic intermediates, which are normally destined for oxidative phosphorylation, in anabolic reactions and activation of the cell death machinery by stimulating mitochondrial membrane permeabilization could therefore be promising therapeutic approaches.