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Retroviral Elements and Their Hosts: Insertional Mutagenesis in the Mouse Germ Line
The prevalence of mouse ERV activity indicates that the genome of the laboratory mouse is presently behind in the “arms race” against invasion. Expand
Genome-Wide Assessments Reveal Extremely High Levels of Polymorphism of Two Active Families of Mouse Endogenous Retroviral Elements
It is found that at least 60% of IAP and 25% of ETn/MusD elements detected in any strain are absent in one or more of the other three strains, suggesting that ERV insertions play a significant role in genetic drift of mouse lines. Expand
Retrotransposon-Induced Heterochromatin Spreading in the Mouse Revealed by Insertional Polymorphisms
It is shown that IAP elements robustly induce H3K9me3 and H4K20me3 marks in flanking genomic DNA, which means that although rare, IAP-induced local heterochromatin spreading into nearby genes may influence expression and, in turn, host fitness. Expand
Genomic deletions and precise removal of transposable elements mediated by short identical DNA segments in primates.
It is shown that retroelements can, in rare cases, be precisely deleted from primate genomes, most likely via recombination between 10- to 20-bp target site duplications flanking the retroelement, suggesting that illegitimate recombinations between short direct repeats has played a significant role in human genome evolution. Expand
Epigenetic mechanism causes Wnt9b deficiency and nonsyndromic cleft lip and palate in the A/WySn mouse strain.
The clf1 mutation in A/WySn is a "metastable epiallele", in which stochastic deficiency in some individuals of DNA methylation of a retrotransposon uniquely inserted near the Wnt9b gene allows transcriptional activity of the retrotranspoon and interference with transcription from Wnt 9b. Expand
Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice.
The clf1 mutation is a genomic alteration present in A/WySn and absent in the ancestral chromosomal segment in CBA/J, and it is predicted that interference with Wnt9b function by this IAP is the clf 1 mutation. Expand
Structure and Expression of Mobile ETnII Retroelements and Their Coding-Competent MusD Relatives in the Mouse
It is shown that ETnII is expressed up to 30-fold more than MusD, which could explain why onlyETnII, but notMusD, elements have been positively identified as new insertions. Expand
Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma
Reanalyzed whole transcriptome data from a large cohort of patients with diffuse large B-cell lymphoma compared with normal B- cell centroblasts to detect genes ectopically expressed through activation of TE promoters and suggest that LTR2-FABP7 may contribute to the pathogenesis of DLBCL in a subgroup of patients. Expand
Ly49 genes in non-rodent mammals
The Ly49 family of natural killer (NK) receptors is encoded by a highly polymorphic multigene family in the mouse and is also present in multiple copies in the rat. However, this gene exists as aExpand
Epigenetic interplay between mouse endogenous retroviruses and host genes
It is shown that genes can be protected from ERV-induced heterochromatin spreading by either blocking the invasion of repressive marks or by spreading euchromatin toward the ERV copy, and that spreading of DNA methylation from ERVs copies toward active gene promoters is rare. Expand