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Neurofilament light chain as a biomarker in neurological disorders
In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. NeurofilamentExpand
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CSF and blood biomarkers for Parkinson's disease
In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers theExpand
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Lower urinary tract symptoms and urodynamic dysfunction in clinically isolated syndromes suggestive of multiple sclerosis
Urinary symptoms associated with multiple sclerosis (MS) are common and negatively impact on quality of life, representing a considerable psychosocial and economic burden, often requiring care andExpand
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A new enzyme-linked immunosorbent assay for neurofilament light in cerebrospinal fluid: analytical validation and clinical evaluation
BackgroundCerebrospinal fluid (CSF) neurofilament light (NfL) is a reliable marker of neuro-axonal damage in different neurological disorders that is related to disease severity. To date, all recentExpand
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Recurrent hyperCKemia with normal muscle biopsy in a pediatric patient with neuromyelitis optica
Neuromyelitis optica (NMO) is a demyelinating disease of the CNS that preferentially affects the optic nerve and spinal cord.1 The presence of circulating autoantibodies (NMO–immunoglobulin G [IgG])Expand
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Synaptic plasticity and experimental autoimmune encephalomyelitis: implications for multiple sclerosis
Structural and functional neuronal plasticity could play a crucial role during the course of multiple sclerosis (MS). The immune system and the central nervous system (CNS) strictly interact inExpand
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Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis
Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal bands (OCB) in multiple sclerosis (MS). Herein, we compared the diagnostic accuracy of CSF OCB and FLCExpand
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Cerebrospinal fluid and serum d-serine concentrations are unaltered across the whole clinical spectrum of Alzheimer's disease.
The diagnosis of Alzheimer's disease (AD) relies on the presence of amyloidosis and tauopathy, as reflected in cerebrospinal fluid (CSF), independently from the clinical stage. Recently, CSF d-serineExpand
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Multiple sclerosis and chronic progressive external ophthalmoplegia associated with a large scale mitochondrial DNA single deletion
Mitochondrial DNA (mtDNA) mutations are responsible for several diseases involving the central nervous system (CNS) [1]. Mitochondrial disorders, and particularly Leber’s hereditary optic neuropathyExpand
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Cerebrospinal fluid neurofilament light chain tracks cognitive impairment in multiple sclerosis
BackgroundCognitive impairment (CI) is a disabling symptom of multiple sclerosis (MS). Axonal damage disrupts neural circuits and may play a role in determining CI, but its detection and monitoringExpand
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