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Impact of fetal and neonatal environment on beta cell function and development of diabetes
The global epidemic of diabetes is a serious threat against health and healthcare expenses. Although genetics is important it does not explain the dramatic increase in incidence, which must involveExpand
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Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell
Aims/hypothesisMaternal low-protein (LP) diet during gestation results in a reduced beta cell mass in the offspring at birth and this may hamper the ability to adapt to high-energy food and sedentaryExpand
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Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone.
Trefoil factors (TFFs) 1, 2, and 3 are expressed in mucosal epithelia. TFFs are particular abundant in the intestine in which they play a crucial role in maintenance and restitution of theExpand
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Functional characteristics of neonatal rat β cells with distinct markers.
Neonatal β cells are considered developmentally immature and hence less glucose responsive. To study the acquisition of mature glucose responsiveness, we compared glucose-regulated redox state,Expand
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Expression and Localization of microRNAs in Perinatal Rat Pancreas: Role of miR-21 in Regulation of Cholesterol Metabolism
Objective To investigate the expression of pancreatic microRNAs (miRNAs) during the period of perinatal beta-cell expansion and maturation in rats, determine the localization of these miRNAs andExpand
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Suppression of FAT/CD36 mRNA by human growth hormone in pancreatic β-cells.
Fatty acid-induced damage in pancreatic β-cells is assumed to play an important role in the development of type 2 diabetes. Lactogens (prolactin, placental lactogen and growth hormone) improve β-cellExpand
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Co‐ordinated regulation of neurogenin‐3 expression in the maternal and fetal pancreas during pregnancy
Several studies have shown increased beta cell mass during pregnancy in both rodents and humans. Proliferation of existing beta cells seems to be the predominant mechanism in rodents, whereas theExpand
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Abstract 208: A novel cell culture surface supports effective formation of three dimensional cancer spheroids in suspension.
The study of cell biology via monolayer cell culture systems is not entirely adequate for the investigation of complex inter-cell and cell to extracellular matrix interactions in vitro. ThreeExpand
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The Nunclon Sphera surface supports formation of three dimensional cancer spheroids in suspension
While monolayer cell culture has been used extensively to study many types of cancers in vitro, 3 dimensional (3D) cultures of cancer spheroids better simulate the in vivo environment and, thereforeExpand