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The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease
In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the pathophysiology of hypertension and organ injury has changed to a major emphasis on the role of theExpand
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Paracrine regulation of the renal microcirculation.
There has been an explosive growth of interest in the multiple interacting paracrine systems that influence renal microvascular function. This review first discusses the membrane activationExpand
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Urinary Angiotensinogen as a Novel Biomarker of the Intrarenal Renin-Angiotensin System Status in Hypertensive Patients
We reported previously that urinary angiotensinogen (UAGT) levels provide a specific index of the intrarenal renin-angiotensin system (RAS) status in angiotensin II–dependent hypertensive rats. ToExpand
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Actions of epoxygenase metabolites on the preglomerular vasculature.
Epoxygenase metabolites of arachidonic acid are produced by the kidney and have been implicated in the control of renal blood flow. This study examined the preglomerular actions of variousExpand
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Neuronal nitric oxide synthase modulates rat renal microvascular function.
This study was performed to determine the influence of neuronal nitric oxide synthase (nNOS) on renal arteriolar tone under conditions of normal, interrupted, and increased volume delivery to theExpand
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Regulation of intrarenal angiotensin II in hypertension.
Intrarenal angiotensin II (Ang II) is regulated by several complex processes involving formation from both systemically delivered and intrarenally formed substrate, as well as receptor-mediatedExpand
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The intrarenal renin-angiotensin system in hypertension.
A 50-year-old woman with type 2 diabetes mellitus and hypertension was admitted to Brigham and Women’s Hospital in Boston for entry into a clinical research protocol involving hemodynamic responsesExpand
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Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions.
Chronic angiotensin (ANG) II infusions into rats lead to augmented intrarenal levels of ANG II and inflammatory factors, impaired renal function, and progressive hypertension. Residual effectsExpand
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Intrarenal production of angiotensin II.
The intrarenal renin-angiotensin system plays a critical role in the paracrine regulation of renal hemodynamics and tubular transport function. Much of the intrarenal angiotensin II (ANG II) isExpand
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The absence of intrarenal ACE protects against hypertension.
Activation of the intrarenal renin-angiotensin system (RAS) can elicit hypertension independently from the systemic RAS. However, the precise mechanisms by which intrarenal Ang II increases bloodExpand
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