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Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro
VCD to determine absolute configuration of natural product molecules: secolignans from Peperomia blanda.
The absolute configuration and solution-state conformers of three peperomin-type secolignans isolated from Peperomia blanda (Piperaceae) are unambiguously determined by using vibrational circular…
Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene
Data indicate a key role for the leucine residue in the structure and function of this oxidosqualene cyclase, which is similar to the friedelin synthase cloned from Kalanchoe daigremontiana.
Crude leaf extracts of Piperaceae species downmodulate inflammatory responses by human monocytes
The crude leaf extracts of P. umbellata, P. fuligineum, and Peperomia obtusifolia elicited an anti-inflammatory response against LPS-challenged monocytes, amplifying the anti- inflammatory response when compared with ketoprofen.
1H NMR determination of adulteration of anabolic steroids in seized drugs
Trypanocidal tetrahydrofuran lignans from Peperomia blanda.
Structure and absolute configuration of a secolignan from Peperomia blanda
Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth (Piperaceae)
The known kavalactones (E)-4-methoxy-6-styryl-2H-pyran-2-one, 4-methoxy6-(3-phenyloxiran-2-yl)-2H-pyran-2-one, 6-(1,2-dihydroxy-2-phenylethyl)-4-methoxy-2H-pyran2-one, the three benzoic acid…
Plant Species from the Atlantic Forest Biome and Their Bioactive Constituents
The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from Maytenus ilicifolia Are Important for Substrate Binding Specificity
Friedelin, a pentacyclic triterpene found in the leaves of the Celastraceae species, demonstrates numerous biological activities and is a precursor of quinonemethide triterpenes, which are promising…