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Gut inflammation provides a respiratory electron acceptor for Salmonella
TLDR
It is shown that reactive oxygen species generated during inflammation react with endogenous, luminal sulphur compounds (thiosulphate) to form a new respiratory electron acceptor, tetrathionate, that allows the pathogen to use respiration to compete with fermenting gut microbes.
Molecular Pathogenesis of Salmonella enterica Serotype Typhimurium-Induced Diarrhea
TLDR
Improved understanding of key events occurring during the complex series of host-pathogen interactions leading to enterocolitis is led to an improved understanding of the molecular pathogenesis.
Salmonella typhimurium leucine‐rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems
TLDR
Two Salmonella typhimurium genes, sspH1 and sSpH2, that encode proteins similar to the Shigella flexneri and Yersinia species TTSS substrates, IpaH and YopM, were identified and deleted, indicating that these genes participate in S. typhIMurium virulence for animals.
Evolution of Host Adaptation inSalmonella enterica
TLDR
The analysis of virulence factors used by different Salmonella serotypes can serve as a powerful guide to the understanding of both the origin of infectious diseases and the emergence of new pathogens.
Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
TLDR
It is shown that nitrate generated as a by-product of the inflammatory response conferred a growth advantage to the commensal bacterium Escherichia coli in the large intestine of mice.
Salmonella enterica Serotype Typhimurium and Its Host-Adapted Variants
TLDR
Salmonella enterica serotypes form a group of pathogens that differ widely in their host range within mammals and birds, and at one end of this spectrum, S.Enterica serotype Typhi is perhaps the most highly host-dependent.
The Salmonella enterica Serotype Typhimurium Effector Proteins SipA, SopA, SopB, SopD, and SopE2 Act in Concert To Induce Diarrhea in Calves
TLDR
SipA, Sop a, SopB, SopD, and SopE2 are major virulence factors responsible for diarrhea during Salmonella serotype Typhimurium infection of calves, and a positive correlation was observed between the severity of histopathological lesions detected in the ileal mucosa and the levels of fluid accumulation induced by the different mutants.
Transposon-Derived Brucella abortusRough Mutants Are Attenuated and Exhibit Reduced Intracellular Survival
TLDR
B. abortus O antigen appears to be essential for extra- and intracellular survival in mice, and a transposon interruption in the gene encoding phosphomannomutase is revealed, suggesting this activity may be required for the synthesis of a full-length core polysaccharide in addition to O antigen.
SipA, SopA, SopB, SopD, and SopE2 Contribute to Salmonella enterica Serotype Typhimurium Invasion of Epithelial Cells
TLDR
The question of which T3SS-1 effectors contribute to the invasion of epithelial cells is revisited by complementing a strain lacking all of the effector genes that are required to cause diarrhea in a calf (a sipA sopABDE2 mutant).
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