L. Frohman

Publications390
h-index71
Citations19,197
Highly Influential Citations310
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Criteria for cure of acromegaly: a consensus statement.
TLDR
This statement summarizes the consensus achieved in discussions to develop a consensus defining the criteria for cure of acromegaly.
Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27 Kip1
The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas.
TLDR
The abnormal expression and subcellular localization of AIP in sporadic pituitary adenomas indicate deranged regulation of this protein during tumorigenesis.
Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial.
TLDR
Pasireotide produced a decrease in UFC levels in 76% of patients with Cushing's disease during the treatment period of 15 d, with direct effects on ACTH release, suggesting that pasireotide holds promise as an effective medical treatment for this disorder.
Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary.
TLDR
It is suggested that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary.
Ovarian function in chronic renal failure: evidence suggesting hypothalamic anovulation.
TLDR
In uremic women, the continued secretion of estrogen, the rise of plasma levels of luteinizing hormone, FSH, and estradiol after clomiphene, and the elevated gonadotropin levels during menopause suggest that the negativeEstradiol feedback, the tonic gonadotropic secretion, andThe pituitary ovarian axis were normal.
Metabolic clearance and secretion rates of human prolactin in normal subjects and in patients with chronic renal failure.
TLDR
Hyperprolactinemia (PRL, >15 ng/ml plasma) was observed in 70% of 73 patients with chronic renal failure (CRF) on maintenance hemodialysis and 94% of the immunoprecipitable radioactivity eluted in the po...
Regulation of growth hormone secretion.
TLDR
Knowledge gained from studies in animals is permitting a better understanding of the mechanisms involved in physiologic GH secretion and altered GH secretion associated with specific disease states in humans.
Guidelines for acromegaly management.
TLDR
There is consensus that integrated treatment decisions should be made by a team including endocrinologists, surgeons, and radiation therapists in managing this complex metabolic disorder, reducing its comorbidities, and ultimately achieving favorable mortality outcomes.
Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12.
The majority of somatotropinomas are sporadic, although a small number occur with a familial aggregation, either as a component of an endocrine neoplasia complex that includes multiple endocrine…
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