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Frailty in older adults: evidence for a phenotype.
TLDR
This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty. Expand
Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care.
TLDR
A narrative review of current understanding of the definitions and distinguishing characteristics of each of these conditions, including their clinical relevance and distinct prevention and therapeutic issues, and how they are related is provided. Expand
The Cardiovascular Health Study: design and rationale.
TLDR
These examinations in CHS permit evaluation of CVD risk factors in older adults, particularly in groups previously under-represented in epidemiologic studies, such as women and the very old. Expand
Frailty consensus: a call to action.
TLDR
For the purposes of optimally managing individuals with physical frailty, all persons older than 70 years and all individuals with significant weight loss (>5%) due to chronic disease should be screened for frailty. Expand
Falls and Fear of Falling: Which Comes First? A Longitudinal Prediction Model Suggests Strategies for Primary and Secondary Prevention
TLDR
The objective was to determine the temporal relationship between falls and fear of falling, and to see whether these two outcomes share predictors. Expand
Incidence of and risk factors for atrial fibrillation in older adults.
TLDR
The incidence of AF in older adults may be higher than estimated by previous population studies and left atrial size appears to be an important risk factor, and the control of blood pressure and glucose may be important in preventing the development of AF. Expand
Phenotype of frailty: characterization in the women's health and aging studies.
TLDR
The frailty definition developed in the CHS is applicable across diverse population samples and identifies a profile of high risk of multiple adverse outcomes and is consistent with the widely held theory that conceptualizes frailty as a syndrome. Expand
Frailty as a predictor of surgical outcomes in older patients.
TLDR
Frailty independently predicts postoperative complications, length of stay, and discharge to a skilled or assisted-living facility in older surgical patients and enhances conventional risk models. Expand
Designing Randomized, Controlled Trials Aimed at Preventing or Delaying Functional Decline and Disability in Frail, Older Persons: A Consensus Report
TLDR
The Interventions on Frailty Working Group developed recommendations to screen, recruit, evaluate, and retain frail older persons in clinical trials. Expand
Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance.
TLDR
It is suggested that adhering to current CPGs in caring for an older person with several comorbidities may have undesirable effects and could create perverse incentives that emphasize the wrong aspects of care for this population and diminish the quality of their care. Expand
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