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Developmental aspects of experimental pulmonary oxygen toxicity.
- L. Frank
- MedicineFree radical biology & medicine
1180 OXYGEN TOXICITY IN NEONATAL AND ADULT ANIMALS OF VARIOUS SPECIES
A lung biochemical basis for the resistance of neonatal animals of certain species to O2 lung injury is supported and these neonates also demonstrate rapid increases in lung antioxidant enzymes, whereas the O2-susceptible adults lack this protective response.
Prenatal development of lung antioxidant enzymes in four species.
OXYGEN TOXICITY IN NEONATAL AND ADULT ANIMALS OF VARIOUS SPECIES.: 1180
Neonatal and adult animals of five species were exposed to 95+% O2. Survival time and changes in lung antioxidant enzyme activity (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase...
Preparation for Birth into an O2-Rich Environment: the Antioxidant Enzymes in the Developing Rabbit Lung
The activities of the antioxidant enzymes in the developing lungs of rabbit fetuses from 10 d before parturition to several days after birth showed similar maturational patterns with significant increases in activity, compared with earlier gestational levels, during the last 3-5 d before birth.
Failure of Premature Rabbits to Increase Antioxidant Enzymes During Hyperoxic Exposure: Increased Susceptibility to Pulmonary Oxygen Toxicity Compared with Term Rabbits
This first reported comparison of prematurely born versus full-term animal responses to hyperoxia might help to explain the clinical observation that the very prematurely born infant is excessively prone to the development of O2-induced lung injury and the progressive development of bronchopulmonary dysplasia.
The Formation of Alveoli in Rat Lung during the Third and Fourth Postnatal Weeks: Effect of Hyperoxia, Dexamethasone, and Deferoxamine
It is suggested that septation continues beyond the 2nd postnatal wk and does not stop abruptly at age 14 d in air-breathing rats and that hyperoxic inhibition of alveolarization during the 3rd and 4th postnatalWk is due to the inhibition of septations of existing or newly generated gas-exchange units during that period of lung development.
Potection from oxygen toxicity with endotoxin. Role of the endogenous antioxidant enzymes of the lung.
- L. Frank, J. Summerville, D. Massaro
- Biology, MedicineThe Journal of clinical investigation
- 1 May 1980
It is concluded that, in the rat, a single dose of endotoxin given even 36 h after the onset of hyperoxic exposure results in marked protection against O(2)-induced lung damage; and the increased lung antioxidant enzyme activity in the endotoxin-treated rats appears to be an essential component of this protective action.
The role of endotoxin in protection of adult rats from oxygen-induced lung toxicity.
After 72h of hyperoxic exposure, the endotoxin-treated rats demonstrated significant increases in lung superoxide dismutase, catalase, and glutathione peroxidase activity, a protectant enzyme response not seen in untreated adult rats.
Developmental Characteristics of Pulmonary Superoxide Dismutase: Relationship to Idiopathic Respiratory Distress Syndrome
The premature infant may be compromised when exposed to the relative hyperoxia of the extrauterine environment by a reduced complement of the enzyme or a reduced ability to increase pulmonary SOD activity in response tohyperoxia.