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Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons
TLDR
It is reported that the Drosophila Arc1 protein forms capsid-like structures that bind darc1 mRNA in neurons and is loaded into extracellular vesicles that are transferred from motorneurons to muscles, suggesting that transfer of dArc1 complexed with its mRNA is required for this function. Expand
Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously.
TLDR
DNA complexed to cationic liposomes becomes highly immunostimulatory and capable of inducing strong antitumor activity when administered systemically, and was dependent on both NK cells and IFN-gamma. Expand
The Roles of the Dystrophin-Associated Glycoprotein Complex at the Synapse
TLDR
Roles for the DGC have been established in consolidation of long-term spatial and recognition memory and the integration of the behavioral and mechanistic studies and the use of this information to identify therapeutic targets are discussed. Expand
Ryks: new partners for Wnts in the developing and regenerating nervous system
TLDR
It is revealed that Wnts signal through Ryk via multiple mechanisms, including nuclear translocation of their intracellular domains and pathways employing Src Family Kinases and members of the canonical Wnt pathway. Expand
Synaptic Defects in a Drosophila Model of Congenital Muscular Dystrophy
TLDR
It is demonstrated that dPOMT1 is required to glycosylate the Drosophila dystroglycan ortholog Dg in vivo, and that this is the likely cause of these synaptic defects because mutations in Dg lead to similar synaptic defects and genetic interaction studies suggest that pomT1 and Dg function in the same pathway. Expand
Dystrophin Is Required for Appropriate Retrograde Control of Neurotransmitter Release at the Drosophila Neuromuscular Junction
TLDR
The results indicate that the postsynaptically localized scaffolding protein Dystrophin is required for appropriate control of neuromuscular synaptic homeostasis. Expand
Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system
TLDR
It is shown that the non-receptor SRC family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system, and that the Src family kinases play novel roles in Wnt5/Derailed- mediated signaling. Expand
The Drosophila Wnt5 protein mediates selective axon fasciculation in the embryonic central nervous system.
TLDR
The Wnt5 protein is predominantly present on posterior commissural axons and at a low level on the anterior commissure and longitudinal projections and it is demonstrated that transcriptional repression of wnt5 in AC neurons by the recently described WNT5 receptor, Derailed, contributes to this largely posterior Commissural localization of Wnt 5 protein. Expand
Type I interferons potently suppress gene expression following gene delivery using liposome(-)DNA complexes.
TLDR
Type I IFNs appear to play a key role in suppressing transgene expression in vivo following systemic nonviral gene delivery using Cationic liposome-DNA complexes. Expand
Derailed regulates development of the Drosophila neuromuscular junction
TLDR
It is shown here that Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor, and structure–function analyses of the Drl protein indicate that normal synaptic growth requires the extracellular Wnt inhibitory factor domain and the intracellular domain, which includes an atypical kinase. Expand
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