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Wild and synanthropic hosts of Leishmania (Viannia) braziliensis in the endemic cutaneous leishmaniasis locality of Amaraji, Pernambuco State, Brazil.
TLDR
It is concluded that small mammals, particularly rodents, are infected with parasites of the subgenus L. (V.) braziliensis, and the isolation of zymodeme IOC/Z74 from humans reinforces the hypothesis that small, ground-loving mammals, such as rodents are the primary reservoirs of L. [Viannia]. Expand
Amazonian malaria vector anopheline relationships interpreted from ITS2 rDNA sequences
TLDR
Rdosomal DNA sequences of the second internal transcribed spacer (ITS2) from samples of 16 species of Anopheles captured in the Amazon Basin, Brazil proved to be a useful tool for species identification and, potentially, to solve taxonomic problems. Expand
NF-κB Drives the Synthesis of Melatonin in RAW 264.7 Macrophages by Inducing the Transcription of the Arylalkylamine-N-Acetyltransferase (AA-NAT) Gene
We demonstrate that during inflammatory responses the nuclear factor kappa B (NF-κB) induces the synthesis of melatonin by macrophages and that macrophage-synthesized melatonin modulates the functionExpand
New PCR Assay Using Glucose-6-Phosphate Dehydrogenase for Identification of Leishmania Species
TLDR
The successful discrimination of L. (Viannia) braziliensis from other parasites of the subgenus Leishmania (Vannia) opens the way to epidemiological studies in areas where more than one species of theSubgenusLeishmania(Viannian) exist, such as Amazonia, as well as follow-up studies after chemotherapy and assessment of clinical prognoses. Expand
The first record in the Americas of an autochthonous case of Leishmania (Leishmania) infantum chagasi in a domestic cat (Felix catus) from Cotia County, São Paulo State, Brazil.
TLDR
The case of feline cutaneous leishmaniasis reported in a domestic cat suggests that natural transmission of this disease is occurring in this area, and that cats could act as a reservoir of L. (L.) infantum chagasi. Expand
The finding of Lutzomyia almerioi and Lutzomyia longipalpis naturally infected by Leishmania spp. in a cutaneous and canine visceral leishmaniases focus in Serra da Bodoquena, Brazil.
To identify natural infections by Leishmania spp. in insect vectors of cutaneous and visceral leishmaniasis, we performed field studies in natural and anthropic environments in the GuaicurusExpand
Discrimination Amongst Leishmania by Polymerase Chain Reaction and Hybridization with Small Subunit Ribosomal DNA Derived Oligonucleotides
TLDR
The method detected as few as 10 cultured organisms and detected parasites in tissue samples from experimentally infected animals, and non‐radioactive labeling showed the same specificity and sensitivity as radioactive probes. Expand
The first records of Leishmania (Leishmania) amazonensis in dogs (Canis familiaris) diagnosed clinically as having canine visceral leishmaniasis from Araçatuba County, São Paulo State, Brazil.
TLDR
Results suggest that L. (L.) amazonensis is being transmitted in the peridomestic habitat and that this parasite is responsible for a clinical condition that is similar to visceral leishmaniasis caused by L. chagasi that is present in the same area. Expand
Leishmania amazonensis Arginase Compartmentalization in the Glycosome Is Important for Parasite Infectivity
TLDR
The results indicate that the proper compartmentalization of L. amazonensis arginase in the glycosome is important for enzyme activity and optimal infectivity and that its proper subcellular location may be essential for this physiological orchestration. Expand
Ribosomal DNA restriction analysis and synthetic oligonucleotide probing in the identification of genera of lower trypanosomatids.
TLDR
Results point to the usefulness of restriction markers as diagnostic tools for distinguishing the lower trypanosomatid genera Crithidia, Herpetomonas, and Phytomonas at the same time revealing a marked complexity within the genus Leptomonas. Expand
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