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Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis.
Clinically isolated syndromes (CIS), such as optic neuritis, brainstem or spinal cord syndromes are frequently the first clinical presentations of multiple sclerosis. However, not all CIS patientsExpand
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Gray matter atrophy is related to long‐term disability in multiple sclerosis
To determine the relation of gray matter (GM) and white matter (WM) brain volumes, and WM lesion load, with clinical outcomes 20 years after first presentation with clinically isolated syndromeExpand
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Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study
Summary Background Concerns regarding potential neurological complications of COVID-19 are being increasingly reported, primarily in small series. Larger studies have been limited by bothExpand
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MRI measures show significant cerebellar gray matter volume loss in multiple sclerosis and are associated with cerebellar dysfunction
Background Regional atrophy measures may offer useful information about the causes of specific clinical deficits in multiple sclerosis (MS). Objective To determine the magnitude of cerebellar grayExpand
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MRI only conversion to multiple sclerosis following a clinically isolated syndrome
Objectives Using current diagnostic criteria, patients who present with a clinically isolated syndrome (CIS) may develop multiple sclerosis (MS) by subsequently exhibiting dissemination in space andExpand
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Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosis
Background In multiple sclerosis, grey matter (GM) damage appears more clinically relevant than either white matter damage or lesion load. Objective We investigated if normal-appearing white matterExpand
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Hippocampal atrophy in relapsing-remitting and primary progressive MS: a comparative study
Background: In multiple sclerosis (MS), demyelination and neuroaxonal damage are seen in the hippocampus, and MRI has revealed hippocampal atrophy. Objectives: To investigate and compare hippocampalExpand
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Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI
Background: Evidence suggests that Epstein-Barr virus (EBV) plays a role in triggering or perpetuating disease activity in multiple sclerosis (MS). Methods: We investigated 100 subjects (50Expand
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Cervical cord and brain grey matter atrophy independently associate with long-term MS disability
In MRI studies of multiple sclerosis (MS), brain grey matter (GM) and spinal cord atrophy correlate with disability.1 2 However, it is uncertain whether they independently associate with long-termExpand
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