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Marinobufagenin Stimulates Fibroblast Collagen Production and Causes Fibrosis in Experimental Uremic Cardiomyopathy
We have observed recently that experimental renal failure in the rat is accompanied by increases in circulating concentrations of the cardiotonic steroid, marinobufagenin (MBG), and substantialExpand
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Introns in gene evolution.
Introns are integral elements of eukaryotic genomes that perform various important functions and actively participate in gene evolution. We review six distinct roles of spliceosomal introns: (1)Expand
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Increased HO-1 Levels Ameliorate Fatty Liver Development Through a Reduction of Heme and Recruitment of FGF21
Obese leptin deficient (ob/ob) mice are a model of adiposity that displays increased levels of fat, glucose, and liver lipids. Our hypothesis is that HO‐1 overexpression ameliorates fatty liverExpand
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Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy.
The cardiotonic steroid marinobufagenin (MBG) has been implicated in the pathogenesis of experimental uremic cardiomyopathy, which is characterized by progressive cardiac fibrosis. We examinedExpand
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HO-1 Induction Improves The Type-1 Cardiorenal Syndrome in Mice With Impaired Angiotensin II–Induced Lymphocyte Activation
Type-1 cardiorenal syndrome, characterized by acute kidney dysfunction secondary to cardiac failure and renal arteriolar vasoconstriction, is mediated by the renin–angiotensin–aldosterone axis andExpand
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Enhancement of COPD biological networks using a web-based collaboration interface.
The construction and application of biological network models is an approach that offers a holistic way to understand biological processes involved in disease. Chronic obstructive pulmonary diseaseExpand
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Inference of Distant Genetic Relations in Humans Using “1000 Genomes”
Nucleotide sequence differences on the whole-genome scale have been computed for 1,092 people from 14 populations publicly available by the 1000 Genomes Project. Total number of differences inExpand
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Atlas of Cryptic Genetic Relatedness Among 1000 Human Genomes
A novel computational method for detecting identical-by-descent (IBD) chromosomal segments between sequenced genomes is presented. It utilizes the distribution patterns of very rare genetic variantsExpand
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Exonic Splicing Enhancers
Exonic splicing enhancers (ESEs) are short motifs in exons that promote both constitutive and alternative splicing. Several splicing factors, known as SR proteins, bind specifically to ESEs duringExpand
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Uremic Cardiomyopathy—An Endogenous Digitalis Intoxication?: Central Role for the Cardiotonic Steroid Marinobufagenin in the Pathogenesis of Experimental Uremic Cardiomyopathy. Hypertension 47:
Since the days of Richard Bright ([1][1]), it has been common knowledge that the heart is a target organ in uremia, and by the beginning of the 20th century it had been recognized that heart failureExpand
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