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A metabolite-regulated potassium channel in rat pancreatic B cells.
In B cells from dispersed rat islet of Langerhans we have identified an inward rectifying voltage-independent K+ channel whose behavior parallels the metabolically regulated potassium permeabilityExpand
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  • Open Access
Activity of ion channels during volume regulation by clonal N1E115 neuroblastoma cells.
  • L. Falke, S. Misler
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 May 1989
When exposed to a hypotonic bathing solution, clonal N1E115 neuroblastoma cells initially swell and then undergo a regulatory volume decrease (RVD). Using cell-attached patch-clamp recording, we haveExpand
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  • Open Access
‘Perforated patch recording’ allows long‐term monitoring of metabolite‐induced electrical activity and voltage‐dependent Ca2+ currents in pancreatic islet B cells
We describe the application of ‘perforated patch recording’ using the pore‐forming antibiotic nystatin, to monitor the electrical activity and underlying ionic currents of rat and human pancreaticExpand
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  • Open Access
Effects of sulfonamides on a metabolite-regulated ATPi-sensitive K+ channel in rat pancreatic B-cells.
Intracellular ATP (ATPi)-sensitive K+ [K+(ATP)] channels are now a recognized site of action of clinically useful hypoglycemic and hyperglycemic sulfonamides. We have further examined the action ofExpand
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Metabolite-Regulated ATP-Sensitive K+ Channel in Human Pancreatic Islet Cells
In patch-clamped surface cells of human islets, we identified an inwardly rectifying, voltage-independent K+ channel that may be a crucial link between substrate metabolism and depolarization-inducedExpand
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Stimulus-Secretion Coupling in β-Cells of Transplantable Human Islets of Langerhans: Evidence for a Critical Role for Ca2+ Entry
With human islets isolated for transplantation, we examined the applicability to humans of a metabolic fuel hypothesis of glucose transduction and a Ca2+ hypothesis of depolarization-secretionExpand
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Dependence on multivalent cations of quantal release of transmitter induced by black widow spider venom.
  • S. Misler, L. Falke
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 September 1987
Application of alpha-latrotoxin (alpha-LT), the active component of black widow spider venom (BWSV), to a vertebrate neuromuscular junction, in the presence of millimolar bath concentrations of Ca2+Expand
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Cation dependence of posttetanic potentiation of neuromuscular transmission.
We have investigated the possibility that much of posttetanic potentiation (PTP) of quantal release of neurotransmitter at the frog neuromuscular junction may be due to posttetanic accumulation ofExpand
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A stretch‐activated anion channel in tobacco protoplasts
Stretch‐activated ion channels have been described in animal cells, where they might serve as mechanoreceptors, baroreceptors or osmoreceptors, as well as in yeast and bacteria, where osmoregulatoryExpand
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Effects of metabolic inhibition by sodium azide on stimulus-secretion coupling in B cells of human islets of Langerhans
Sodium azide (NaN3), a reversible inhibitor of mitochondrial respiration, blocks glucose-induced electrical activity and insulin secretion in human pancreatic islet B cells. Here we show that briefExpand
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