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Domino Reactions in Organic Synthesis.
- L. F. Tietze
- Chemistry, Medicine
- Chemical reviews
- 28 May 1996
Introduction Cationic domino reactions Anionic domino reactions Radical domino reactions Pericyclic domino reactions Photochemically induced domino processes Transition metal catalysis Domino… Expand
Prodrugs for targeted tumor therapies: recent developments in ADEPT, GDEPT and PMT.
The treatment of cancer with common anti-proliferative agents generally suffers from an insufficient differentiation between normal and malignant cells which results in extensive side effects. To… Expand
Antibody‐Directed Enzyme Prodrug Therapy: A Promising Approach for a Selective Treatment of Cancer Based on Prodrugs and Monoclonal Antibodies
The antibody‐directed enzyme prodrug therapy allows a selective liberation of cytotoxic agents from non‐toxic prodrugs in cancerous tissue by targeted antibody–enzyme conjugates. We have developed a… Expand
Synthesis of Highly Functionalized Anthraquinones and Evaluation of Their Antitumor Activity
Highly functionalized anthraquinones which derive from the natural products mensacarcin, islandicin, and chrysophanol have been efficiently synthesized using a Diels–Alder reaction as key step. The… Expand
Natural Product Hybrids as New Leads for Drug Discovery
Synthesis of Novel Structurally Simplified Estrogen Analogues with Electron‐Donating Groups in Ring A.
SYNTHESIS 2009, No. 12, pp 2040–2060xx.xx.2009 Advanced online publication: 14.05.2009 DOI: 10.1055/s-0029-1216810; Art ID: T20108SS © Georg Thieme Verlag Stuttgart · New York Abstract: A library of… Expand
Natural product hybrids as new leads for drug discovery.
Natural products play an important role in the development of drugs, especially for the treatment of infections and cancer, as well as immunosuppressive compounds. However, the number of natural… Expand
Domino reactions in the synthesis of heterocyclic natural products and analogs
Domino reactions are defined as processes of two or more bond-forming reactions under identical conditions, in which the subsequent transformation takes place at the functionalities obtained in the… Expand
Hydrogen ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro.
- E. Jähde, K. Glüsenkamp, I. Klünder, D. Hülser, L. F. Tietze, M. F. Rajewsky
- Cancer research
- 1 June 1989
Aerobic glycolysis, a metabolic characteristic of malignant cells, can be exploited to increase the concentration of lactic acid selectivity in tumor tissues in vivo by systemic administration of… Expand
A strategy for tumor-selective chemotherapy by enzymatic liberation of seco-duocarmycin SA-derivatives from nontoxic prodrugs.
- L. F. Tietze, M. Lieb, T. Herzig, F. Haunert, I. Schuberth
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 July 2001
Immuno-conjugates obtained by linking enzymes with appropriate monoclonal antibodies, which bind to tumor-associated antigens, can be employed in a tumor-selective antibody directed enzyme prodrug… Expand