Skip to search formSkip to main contentSkip to account menu
Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines.
View on PubMed
Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses
TLDR
It is demonstrated that arbidol possesses micromolar-level anti-viral effects in Vero cells infected with Zika virus, West Nile virus, and tick-borne encephalitis virus, three medically important representatives of the arthropod-borne flaviviruses.
View PDF
Characterisation of Zika virus infection in primary human astrocytes
TLDR
The results confirm that human astrocytes are sensitive to ZikV infection and could be a source of proinflammatory cytokines in the ZIKV-infected brain tissue.
View on Springer
Nucleoside Inhibitors of Zika Virus.
TLDR
Antiviral activity was identified when 2'-C-methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.
View on PubMed
Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses.
View on PubMed
Electron Tomography Analysis of Tick-Borne Encephalitis Virus Infection in Human Neurons
TLDR
This study was the first to characterize the 3D topographical organization of membranous whorls and autophagic vacuoles in TBEV-infected human neurons, using advanced high-pressure freezing and freeze-substitution techniques to achieve optimal preservation of infected cell architecture.
View on PubMed
An Approach for Zika Virus Inhibition Using Homology Structure of the Envelope Protein
TLDR
A holistic, simulation-based approach to predict compounds that will inhibit ligand binding onto a structurally unresolved protein, in this case the Zika virus envelope protein (ZVEP), by developing a three-dimensional general structure and analyzing sites at which ligands and small drug-like molecules interact is reported.
View on Springer
Single-domain antibody fragments derived from heavy-chain antibodies: a review
TLDR
The typical properties of heavy-chain antibodies and sdAb fragments which differentiate them from conventional antibodies and other available recombinant fragments are highlighted, and their extremely broad application potential, mainly in human disease therapy is emphasized.
View via Publisher
An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice
TLDR
It is demonstrated that an E460D substitution in the active site of TBEV RNA-dependent RNA polymerase (RdRp) confers resistance to galidesivir in cell culture, which contributes to understanding the molecular basis of galidesvir antiviral activity.
View on ASMUSA
Tick-Borne Encephalitis Virus Vaccines Contain Non-Structural Protein 1 Antigen and May Elicit NS1-Specific Antibody Responses in Vaccinated Individuals
TLDR
The contribution of NS1-specific antibodies to protection against TBE was demonstrated by immunization of mice with purified NS1 antigen, which led to a significant prolongation of the mean survival time after lethal virus challenge, indicating that stimulation of anti-NS1 immunity by the TBE vaccines may increase their protective effect.
View PDF
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License