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- Publications
- Influence
Lipid patches in membrane protein oligomers: crystal structure of the bacteriorhodopsin-lipid complex.
- L. Essen, R. Siegert, W. D. Lehmann, D. Oesterhelt
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 29 September 1998
Heterogenous nucleation on small molecule crystals causes a monoclinic crystal form of bacteriorhodopsin (BR) in which trimers of this membrane protein pack differently than in native purple… Expand
Structure of the light-driven chloride pump halorhodopsin at 1.8 A resolution.
- M. Kolbe, H. Besir, L. Essen, D. Oesterhelt
- Chemistry, Medicine
- Science
- 26 May 2000
Halorhodopsin, an archaeal rhodopsin ubiquitous in Haloarchaea, uses light energy to pump chloride through biological membranes. Halorhodopsin crystals were grown in a cubic lipidic phase, which… Expand
Group II chaperonins: new TRiC(k)s and turns of a protein folding machine.
- I. Gutsche, L. Essen, W. Baumeister
- Biology, Medicine
- Journal of molecular biology
- 22 October 1999
In the past decade, the eubacterial group I chaperonin GroEL became the paradigm of a protein folding machine. More recently, electron microscopy and X-ray crystallography offered insights into the… Expand
A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.
- L. Essen, O. Perisic, D. Lynch, M. Katan, R. L. Williams
- Chemistry, Medicine
- Biochemistry
- 11 March 1997
We have determined the crystal structures of complexes of phosphoinositide-specific phospholipase C-delta1 from rat with calcium, barium, and lanthanum at 2.5-2.6 A resolution. Binding of these metal… Expand
Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C.
- L. Essen, O. Perisic, M. Katan, Y. Wu, M. Roberts, R. Williams
- Chemistry, Medicine
- Biochemistry
- 18 February 1997
The crystal structures of various ternary complexes of phosphoinositide-specific phospholipase C-delta 1 from rat with calcium and inositol phosphates have been determined at 2.30-2.95 A resolution.… Expand
Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state
Cyclic AMP is a major trigger of the differentiation process of Trypanosoma brucei, a bloodstream parasite causing sleeping sickness. Its generation in trypanosomes is accomplished by a unique… Expand
Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C.
- D. W. Heinz, L. Essen, R. Williams
- Biology, Medicine
- Journal of molecular biology
- 30 January 1998
Phosphoinositide-specific phospholipases C (PI-PLCs) are ubiquitous enzymes that catalyse the hydrolysis of phosphoinositides to inositol phosphates and diacylglycerol (DAG). Whereas the eukaryotic… Expand
Crystal structure of the bifunctional soybean Bowman-Birk inhibitor at 0.28-nm resolution. Structural peculiarities in a folded protein conformation.
- R. H. Voss, U. Ermler, L. Essen, G. Wenzl, Y. Kim, P. Flecker
- Chemistry, Medicine
- European journal of biochemistry
- 1 November 1996
The Bowman-Birk inhibitor from soybean is a small protein that contains a binary arrangement of trypsin-reactive and chymotrypsin-reactive subdomains. In this report, the crystal structure of this… Expand
Light-driven DNA repair by photolyases
Abstract.DNA photolyases are highly efficient light-driven DNA repair enzymes which revert the genomedamaging effects caused by ultraviolet (UV) radiation. These enzymes occur in almost all living… Expand
C2 domain conformational changes in phospholipase C-delta 1.
- J. Grobler, L. Essen, R. Williams, J. Hurley
- Chemistry, Medicine
- Nature structural biology
- 12 February 1997
The structure of the PH-domain truncated core of rat phosphoinositide-specific phospholipase C-delta 1 has been determined at 2.4 A resolution and compared to the structure previously determined in a… Expand