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Lipid patches in membrane protein oligomers: crystal structure of the bacteriorhodopsin-lipid complex.
Heterogenous nucleation on small molecule crystals causes a monoclinic crystal form of bacteriorhodopsin (BR) in which trimers of this membrane protein pack differently than in native purpleExpand
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Structure of the light-driven chloride pump halorhodopsin at 1.8 A resolution.
Halorhodopsin, an archaeal rhodopsin ubiquitous in Haloarchaea, uses light energy to pump chloride through biological membranes. Halorhodopsin crystals were grown in a cubic lipidic phase, whichExpand
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Group II chaperonins: new TRiC(k)s and turns of a protein folding machine.
In the past decade, the eubacterial group I chaperonin GroEL became the paradigm of a protein folding machine. More recently, electron microscopy and X-ray crystallography offered insights into theExpand
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A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.
We have determined the crystal structures of complexes of phosphoinositide-specific phospholipase C-delta1 from rat with calcium, barium, and lanthanum at 2.5-2.6 A resolution. Binding of these metalExpand
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Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C.
The crystal structures of various ternary complexes of phosphoinositide-specific phospholipase C-delta 1 from rat with calcium and inositol phosphates have been determined at 2.30-2.95 A resolution.Expand
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Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state
Cyclic AMP is a major trigger of the differentiation process of Trypanosoma brucei, a bloodstream parasite causing sleeping sickness. Its generation in trypanosomes is accomplished by a uniqueExpand
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Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C.
Phosphoinositide-specific phospholipases C (PI-PLCs) are ubiquitous enzymes that catalyse the hydrolysis of phosphoinositides to inositol phosphates and diacylglycerol (DAG). Whereas the eukaryoticExpand
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Crystal structure of the bifunctional soybean Bowman-Birk inhibitor at 0.28-nm resolution. Structural peculiarities in a folded protein conformation.
The Bowman-Birk inhibitor from soybean is a small protein that contains a binary arrangement of trypsin-reactive and chymotrypsin-reactive subdomains. In this report, the crystal structure of thisExpand
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Light-driven DNA repair by photolyases
  • L. Essen, T. Klar
  • Chemistry, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • 15 May 2006
Abstract.DNA photolyases are highly efficient light-driven DNA repair enzymes which revert the genomedamaging effects caused by ultraviolet (UV) radiation. These enzymes occur in almost all livingExpand
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C2 domain conformational changes in phospholipase C-delta 1.
The structure of the PH-domain truncated core of rat phosphoinositide-specific phospholipase C-delta 1 has been determined at 2.4 A resolution and compared to the structure previously determined in aExpand
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